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• W1993676324 abstract "Novel cholesterol biosynthesis inhibitors, a group of pyridylethanol(phenylethyl)amine derivatives, were synthesized. Sterol profiling assay in the human hepatoma HepG2 cells revealed that compounds target human lanosterol 14α-demethylase (CYP51). Structure–activity relationship study of the binding with the overexpressed human CYP51 indicates that the pyridine binds within the heme binding pocket in an analogy with the azoles." @default.
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• W1993676324 date "2008-01-01" @default.
• W1993676324 modified "2023-10-18" @default.
• W1993676324 title "Novel cholesterol biosynthesis inhibitors targeting human lanosterol 14α-demethylase (CYP51)" @default.
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• W1993676324 doi "https://doi.org/10.1016/j.bmc.2007.10.001" @default.
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