Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993677761> ?p ?o ?g. }
- W1993677761 endingPage "93" @default.
- W1993677761 startingPage "83" @default.
- W1993677761 abstract "Selective depletion of macrophages from tissues in vivo can be used to investigate whether these cells are playing a role in defined biological processes. This question is particularly relevant to various host defense mechanisms. We have developed a macrophage ‘suicide’ technique, using the liposome mediated intracellular delivery of dichloromethylene-bisphosphonate (Cl2MBP or clodronate). The method is specific with respect to phagocytic cells of the mononuclear phagocyte system (MPS) for the following reasons: (1) The natural fate of liposomes is phagocytosis. (2) Once ingested by macrophages, the phospholipid bilayers of the liposomes are disrupted under the influence of lysosomal phospholipases. (3) Cl2MBP intracellularly released in this way does not easily escape from the cell by crossing the cell membranes. (4) Cl2MBP released in the circulation from dead macrophages or by leakage from liposomes, will not easily enter non-phagocytic cells and has an extremely short half life in the circulation and body fluids. In the present review, the preparation of Cl2MBP-liposomes has been described in detail. Furthermore, the mechanism of action of the new approach and its applicabilities are discussed." @default.
- W1993677761 created "2016-06-24" @default.
- W1993677761 creator A5021982925 @default.
- W1993677761 creator A5079003683 @default.
- W1993677761 date "1994-09-01" @default.
- W1993677761 modified "2023-10-09" @default.
- W1993677761 title "Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications" @default.
- W1993677761 cites W1210607603 @default.
- W1993677761 cites W1441643776 @default.
- W1993677761 cites W1496648942 @default.
- W1993677761 cites W1592595415 @default.
- W1993677761 cites W1608305635 @default.
- W1993677761 cites W1902223278 @default.
- W1993677761 cites W1972270885 @default.
- W1993677761 cites W1972727868 @default.
- W1993677761 cites W1976374552 @default.
- W1993677761 cites W1976695616 @default.
- W1993677761 cites W1984452446 @default.
- W1993677761 cites W1989524620 @default.
- W1993677761 cites W1993945357 @default.
- W1993677761 cites W1997653917 @default.
- W1993677761 cites W2010587003 @default.
- W1993677761 cites W2025590941 @default.
- W1993677761 cites W2025680525 @default.
- W1993677761 cites W2028924996 @default.
- W1993677761 cites W2036230771 @default.
- W1993677761 cites W2037950123 @default.
- W1993677761 cites W2042644461 @default.
- W1993677761 cites W2050391272 @default.
- W1993677761 cites W2057973214 @default.
- W1993677761 cites W2064756683 @default.
- W1993677761 cites W2065840171 @default.
- W1993677761 cites W2074096455 @default.
- W1993677761 cites W2079078912 @default.
- W1993677761 cites W2090232052 @default.
- W1993677761 cites W2126696395 @default.
- W1993677761 cites W2127559758 @default.
- W1993677761 cites W2129449449 @default.
- W1993677761 cites W2133967889 @default.
- W1993677761 cites W2151363901 @default.
- W1993677761 cites W2183272231 @default.
- W1993677761 cites W2183796854 @default.
- W1993677761 cites W2260773222 @default.
- W1993677761 cites W2314632132 @default.
- W1993677761 cites W2321864371 @default.
- W1993677761 cites W2325074086 @default.
- W1993677761 cites W2409658494 @default.
- W1993677761 cites W4248587388 @default.
- W1993677761 doi "https://doi.org/10.1016/0022-1759(94)90012-4" @default.
- W1993677761 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8083541" @default.
- W1993677761 hasPublicationYear "1994" @default.
- W1993677761 type Work @default.
- W1993677761 sameAs 1993677761 @default.
- W1993677761 citedByCount "1620" @default.
- W1993677761 countsByYear W19936777612012 @default.
- W1993677761 countsByYear W19936777612013 @default.
- W1993677761 countsByYear W19936777612014 @default.
- W1993677761 countsByYear W19936777612015 @default.
- W1993677761 countsByYear W19936777612016 @default.
- W1993677761 countsByYear W19936777612017 @default.
- W1993677761 countsByYear W19936777612018 @default.
- W1993677761 countsByYear W19936777612019 @default.
- W1993677761 countsByYear W19936777612020 @default.
- W1993677761 countsByYear W19936777612021 @default.
- W1993677761 countsByYear W19936777612022 @default.
- W1993677761 countsByYear W19936777612023 @default.
- W1993677761 crossrefType "journal-article" @default.
- W1993677761 hasAuthorship W1993677761A5021982925 @default.
- W1993677761 hasAuthorship W1993677761A5079003683 @default.
- W1993677761 hasConcept C12554922 @default.
- W1993677761 hasConcept C1491633281 @default.
- W1993677761 hasConcept C160448771 @default.
- W1993677761 hasConcept C185154212 @default.
- W1993677761 hasConcept C185592680 @default.
- W1993677761 hasConcept C19702531 @default.
- W1993677761 hasConcept C202751555 @default.
- W1993677761 hasConcept C203014093 @default.
- W1993677761 hasConcept C2776120743 @default.
- W1993677761 hasConcept C2777700362 @default.
- W1993677761 hasConcept C2778918659 @default.
- W1993677761 hasConcept C2779244956 @default.
- W1993677761 hasConcept C28005876 @default.
- W1993677761 hasConcept C40017333 @default.
- W1993677761 hasConcept C41625074 @default.
- W1993677761 hasConcept C55493867 @default.
- W1993677761 hasConcept C86803240 @default.
- W1993677761 hasConcept C95444343 @default.
- W1993677761 hasConceptScore W1993677761C12554922 @default.
- W1993677761 hasConceptScore W1993677761C1491633281 @default.
- W1993677761 hasConceptScore W1993677761C160448771 @default.
- W1993677761 hasConceptScore W1993677761C185154212 @default.
- W1993677761 hasConceptScore W1993677761C185592680 @default.
- W1993677761 hasConceptScore W1993677761C19702531 @default.
- W1993677761 hasConceptScore W1993677761C202751555 @default.
- W1993677761 hasConceptScore W1993677761C203014093 @default.
- W1993677761 hasConceptScore W1993677761C2776120743 @default.
- W1993677761 hasConceptScore W1993677761C2777700362 @default.
- W1993677761 hasConceptScore W1993677761C2778918659 @default.