Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993685576> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1993685576 abstract "Abstract To investigate whether lactic acid could inhibit the LPS-activation of NF-κB p65 in rat intestinal mucosa microvascular endothelial cells (RIMMVECs), RIMMVECs, cultured in vitro, were pretreated with different concentrations of lactic acid and then exposed to lipopolysaccharide (LPS). Cells and cell culture media were then collected at different time intervals. Production of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) was examined at the protein level by enzyme-linked immunosorbent assay. The influence of lactic acid on the LPS-activation of NF-κB was examined at mRNA and protein levels by real-time quantitative PCR and Western blot analysis, respectively. TNF-α and IL-6 protein levels were significantly decreased after pretreatment with lactic acid compared with cells exposed to LPS only. After pretreatment with 7.5, 5.0, and 2.5 μL mL−1 lactic acid, NF-κB mRNA levels were increased by 1.51-, 2.62- and 3.00-fold, respectively, compared with levels in control cells without LPS treatment. Western blot analysis indicated that the level of NF-κB p65 in the lactic acid-pretreated group was significantly lower than that in the group treated with LPS only (positive control) and was unchanged compared with the group without LPS treatment (blank control). These results suggest that lactic acid may inhibit LPS-activation of NF-κB, leading to the down-regulation of TNF-α and IL-6." @default.
- W1993685576 created "2016-06-24" @default.
- W1993685576 creator A5009979841 @default.
- W1993685576 creator A5019606599 @default.
- W1993685576 creator A5035282947 @default.
- W1993685576 creator A5040799578 @default.
- W1993685576 creator A5079313835 @default.
- W1993685576 date "2011-06-01" @default.
- W1993685576 modified "2023-09-23" @default.
- W1993685576 title "Lactic Acid Inhibits NF-κB Activation by Lipopolysaccharide in Rat Intestinal Mucosa Microvascular Endothelial Cells" @default.
- W1993685576 cites W1805538867 @default.
- W1993685576 cites W1972360982 @default.
- W1993685576 cites W2029818552 @default.
- W1993685576 cites W2064711537 @default.
- W1993685576 cites W2096166085 @default.
- W1993685576 cites W2098087741 @default.
- W1993685576 cites W2109083880 @default.
- W1993685576 cites W2117107523 @default.
- W1993685576 cites W2134714663 @default.
- W1993685576 cites W2139319526 @default.
- W1993685576 cites W2140632548 @default.
- W1993685576 cites W2160943316 @default.
- W1993685576 cites W2182334087 @default.
- W1993685576 cites W2315613727 @default.
- W1993685576 cites W2343513763 @default.
- W1993685576 cites W2412611523 @default.
- W1993685576 cites W2415196759 @default.
- W1993685576 cites W2038890616 @default.
- W1993685576 doi "https://doi.org/10.1016/s1671-2927(11)60081-3" @default.
- W1993685576 hasPublicationYear "2011" @default.
- W1993685576 type Work @default.
- W1993685576 sameAs 1993685576 @default.
- W1993685576 citedByCount "4" @default.
- W1993685576 countsByYear W19936855762013 @default.
- W1993685576 countsByYear W19936855762018 @default.
- W1993685576 countsByYear W19936855762019 @default.
- W1993685576 countsByYear W19936855762021 @default.
- W1993685576 crossrefType "journal-article" @default.
- W1993685576 hasAuthorship W1993685576A5009979841 @default.
- W1993685576 hasAuthorship W1993685576A5019606599 @default.
- W1993685576 hasAuthorship W1993685576A5035282947 @default.
- W1993685576 hasAuthorship W1993685576A5040799578 @default.
- W1993685576 hasAuthorship W1993685576A5079313835 @default.
- W1993685576 hasConcept C104317684 @default.
- W1993685576 hasConcept C123012128 @default.
- W1993685576 hasConcept C134018914 @default.
- W1993685576 hasConcept C153911025 @default.
- W1993685576 hasConcept C17991360 @default.
- W1993685576 hasConcept C185592680 @default.
- W1993685576 hasConcept C202751555 @default.
- W1993685576 hasConcept C2775920511 @default.
- W1993685576 hasConcept C2776415932 @default.
- W1993685576 hasConcept C2778754761 @default.
- W1993685576 hasConcept C523546767 @default.
- W1993685576 hasConcept C54355233 @default.
- W1993685576 hasConcept C55493867 @default.
- W1993685576 hasConcept C85265743 @default.
- W1993685576 hasConcept C86803240 @default.
- W1993685576 hasConceptScore W1993685576C104317684 @default.
- W1993685576 hasConceptScore W1993685576C123012128 @default.
- W1993685576 hasConceptScore W1993685576C134018914 @default.
- W1993685576 hasConceptScore W1993685576C153911025 @default.
- W1993685576 hasConceptScore W1993685576C17991360 @default.
- W1993685576 hasConceptScore W1993685576C185592680 @default.
- W1993685576 hasConceptScore W1993685576C202751555 @default.
- W1993685576 hasConceptScore W1993685576C2775920511 @default.
- W1993685576 hasConceptScore W1993685576C2776415932 @default.
- W1993685576 hasConceptScore W1993685576C2778754761 @default.
- W1993685576 hasConceptScore W1993685576C523546767 @default.
- W1993685576 hasConceptScore W1993685576C54355233 @default.
- W1993685576 hasConceptScore W1993685576C55493867 @default.
- W1993685576 hasConceptScore W1993685576C85265743 @default.
- W1993685576 hasConceptScore W1993685576C86803240 @default.
- W1993685576 hasLocation W19936855761 @default.
- W1993685576 hasOpenAccess W1993685576 @default.
- W1993685576 hasPrimaryLocation W19936855761 @default.
- W1993685576 hasRelatedWork W2056438975 @default.
- W1993685576 hasRelatedWork W2130983605 @default.
- W1993685576 hasRelatedWork W2151199145 @default.
- W1993685576 hasRelatedWork W2361615234 @default.
- W1993685576 hasRelatedWork W2373605790 @default.
- W1993685576 hasRelatedWork W2377000471 @default.
- W1993685576 hasRelatedWork W2383483568 @default.
- W1993685576 hasRelatedWork W2391112504 @default.
- W1993685576 hasRelatedWork W2416665945 @default.
- W1993685576 hasRelatedWork W2594137761 @default.
- W1993685576 hasRelatedWork W2611326405 @default.
- W1993685576 hasRelatedWork W264691461 @default.
- W1993685576 hasRelatedWork W2984256442 @default.
- W1993685576 hasRelatedWork W2984327470 @default.
- W1993685576 hasRelatedWork W3024168482 @default.
- W1993685576 hasRelatedWork W3028838276 @default.
- W1993685576 hasRelatedWork W3032135328 @default.
- W1993685576 hasRelatedWork W3141520235 @default.
- W1993685576 hasRelatedWork W3143655211 @default.
- W1993685576 hasRelatedWork W3031538461 @default.
- W1993685576 isParatext "false" @default.
- W1993685576 isRetracted "false" @default.
- W1993685576 magId "1993685576" @default.
- W1993685576 workType "article" @default.