Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993695201> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1993695201 endingPage "161" @default.
- W1993695201 startingPage "153" @default.
- W1993695201 abstract "The interaction between dl-sotalol and isoproterenol on the ventricular effective refractory period (VERP) and conduction were examined in an electrophysiologic study of 9 patients at drug-free baseline, after 14 days of dlsotalol administration (320mg/day), and after the administration of isoproterenol. In all 9 patients, ventricular tachyarrhythmia could not be induced after dl-sotalol treatment. Isoproterenol was administered as a loading dosage of 0.025μg/kg for 5min with a maintenance dosage of 0.0025μg/kg/min. The VERP and the QRS duration were determined at paced cycle lengths of 600, 400 and 300msec. DL-sotalol and dl-sotalol+isoproterenol had no effect on ventricular conduction at the three cycle lengths. The VERP was significantly prolonged after dl-sotalol treatment at paced cycle lengths of 600 (241±16 to 302±28msec, p<0.001), 400 (223±21 to 280±23msec, p<0.001) and 300msec (202±16 to 256±24msec, p<0.005), but there was a parallel shift of the VERP, suggesting the absence of use-dependent effects on the VERP. The dl-sotalol-induced VERP prolongation was partially reversed by isoproterenol, but it remained significantly prolonged above baseline values at paced cycle lengths of 600 (241±16 to 281±18msec, p<0.01), 400 (223±21 to 258±20msec, p<0.01) and 300msec (202±16 to 247±22msec, p<0.01). The shortening of the VERP was greater at longer basic cycle lengths (600 and 400msec) than at the shorter paced cycle length (300msec, p<.05), but the percentage increase of the VERP was similar at the three basic cycle lengths of 600 (16%), 400 (15%) and 300 (20%)msec, indicating the lack of reverse use-dependency. The absence of reverse use-dependency of dl-sotalol on the VERP, even after isoproterenol administration, may be beneficial in the therapy of ventricular tachyarrhythmias and may account in part for the high efficacy of this drug." @default.
- W1993695201 created "2016-06-24" @default.
- W1993695201 creator A5003308408 @default.
- W1993695201 creator A5049605184 @default.
- W1993695201 creator A5055227838 @default.
- W1993695201 creator A5060689933 @default.
- W1993695201 creator A5076393967 @default.
- W1993695201 date "1998-01-01" @default.
- W1993695201 modified "2023-10-16" @default.
- W1993695201 title "Use-dependent Electrophysiologic Effects of DL-sotalol and Modulation by Isoproterenol in the Human Ventricle." @default.
- W1993695201 cites W1967148960 @default.
- W1993695201 cites W1967151871 @default.
- W1993695201 cites W1968505666 @default.
- W1993695201 cites W2002374666 @default.
- W1993695201 cites W2006584081 @default.
- W1993695201 cites W2009996971 @default.
- W1993695201 cites W2020859911 @default.
- W1993695201 cites W2020961312 @default.
- W1993695201 cites W2029481286 @default.
- W1993695201 cites W2029833137 @default.
- W1993695201 cites W2035257119 @default.
- W1993695201 cites W2042217106 @default.
- W1993695201 cites W2048555011 @default.
- W1993695201 cites W2052732414 @default.
- W1993695201 cites W2062279368 @default.
- W1993695201 cites W2065652372 @default.
- W1993695201 cites W2072494766 @default.
- W1993695201 cites W2085773239 @default.
- W1993695201 cites W2086680318 @default.
- W1993695201 cites W2118581859 @default.
- W1993695201 cites W2168806904 @default.
- W1993695201 cites W2262933830 @default.
- W1993695201 cites W2272051720 @default.
- W1993695201 cites W2395280272 @default.
- W1993695201 cites W3148615618 @default.
- W1993695201 doi "https://doi.org/10.1536/ihj.39.153" @default.
- W1993695201 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9687824" @default.
- W1993695201 hasPublicationYear "1998" @default.
- W1993695201 type Work @default.
- W1993695201 sameAs 1993695201 @default.
- W1993695201 citedByCount "2" @default.
- W1993695201 crossrefType "journal-article" @default.
- W1993695201 hasAuthorship W1993695201A5003308408 @default.
- W1993695201 hasAuthorship W1993695201A5049605184 @default.
- W1993695201 hasAuthorship W1993695201A5055227838 @default.
- W1993695201 hasAuthorship W1993695201A5060689933 @default.
- W1993695201 hasAuthorship W1993695201A5076393967 @default.
- W1993695201 hasBestOaLocation W19936952011 @default.
- W1993695201 hasConcept C111773187 @default.
- W1993695201 hasConcept C126322002 @default.
- W1993695201 hasConcept C134018914 @default.
- W1993695201 hasConcept C164705383 @default.
- W1993695201 hasConcept C189327125 @default.
- W1993695201 hasConcept C2776639339 @default.
- W1993695201 hasConcept C2778921608 @default.
- W1993695201 hasConcept C2779161974 @default.
- W1993695201 hasConcept C42219234 @default.
- W1993695201 hasConcept C70616116 @default.
- W1993695201 hasConcept C71924100 @default.
- W1993695201 hasConceptScore W1993695201C111773187 @default.
- W1993695201 hasConceptScore W1993695201C126322002 @default.
- W1993695201 hasConceptScore W1993695201C134018914 @default.
- W1993695201 hasConceptScore W1993695201C164705383 @default.
- W1993695201 hasConceptScore W1993695201C189327125 @default.
- W1993695201 hasConceptScore W1993695201C2776639339 @default.
- W1993695201 hasConceptScore W1993695201C2778921608 @default.
- W1993695201 hasConceptScore W1993695201C2779161974 @default.
- W1993695201 hasConceptScore W1993695201C42219234 @default.
- W1993695201 hasConceptScore W1993695201C70616116 @default.
- W1993695201 hasConceptScore W1993695201C71924100 @default.
- W1993695201 hasIssue "2" @default.
- W1993695201 hasLocation W19936952011 @default.
- W1993695201 hasLocation W19936952012 @default.
- W1993695201 hasOpenAccess W1993695201 @default.
- W1993695201 hasPrimaryLocation W19936952011 @default.
- W1993695201 hasRelatedWork W1603992705 @default.
- W1993695201 hasRelatedWork W1974387551 @default.
- W1993695201 hasRelatedWork W1985854880 @default.
- W1993695201 hasRelatedWork W1990420736 @default.
- W1993695201 hasRelatedWork W2046452918 @default.
- W1993695201 hasRelatedWork W2066278430 @default.
- W1993695201 hasRelatedWork W2139343636 @default.
- W1993695201 hasRelatedWork W2171708115 @default.
- W1993695201 hasRelatedWork W2398868401 @default.
- W1993695201 hasRelatedWork W2408820213 @default.
- W1993695201 hasVolume "39" @default.
- W1993695201 isParatext "false" @default.
- W1993695201 isRetracted "false" @default.
- W1993695201 magId "1993695201" @default.
- W1993695201 workType "article" @default.