FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993702997> ?p ?o ?g. }

• W1993702997 endingPage "155" @default.
• W1993702997 startingPage "147" @default.
• W1993702997 abstract "The aim of this study was to determine whether overexpression of stress proteins (SPs) could be a sensitive biomarker for cell injury due to exposure to low doses of volatile organic compounds (VOCs) such as benzene, ethylbenzene, toluene, xylene, and chlorinated derivatives (ClB). Sublethal and cytotoxic threshold concentrations of the VOCs were determined by studying the growth rate of normal (fibroblasts) or tumor-derived human cell lines (A549, HepG2) exposed for 4 days to VOCs. Changes in SP expression as a function of concentrations were investigated by Western blotting.VOC toxicity was found to be correlated with their degree of chlorination and their hydrophobicity. Cytotoxic threshold concentrations (no-observed effect concentration, NOEC) were found to be similar for the three cell lines. It was observed that using a mixture of VOCs, each of them at concentration below the NOEC, resulted in an actual toxicity to the cells. This finding reveals a synergistic effect and should be taken into account when assessing threshold risk and exposure limit values in the worker's environment when several pollutants may be present. HSP72 and HSP90 expression levels were not affected whereas GRP78 expression was increased by all the VOCs. Taking into account the specific molecular function of GRP78, it suggests that VOC exposure results in misfolded or underglycosylated protein accumulation in the endoplasmic reticulum. GRP78 overexpression was closely related to the magnitude of growth inhibition due to increasing concentrations of each VOC. The overexpression was found to be significant for concentrations 5 to 30 times higher than NOEC, indicating that, under our experimental conditions, GRP78 expression cannot be considered as a sensitive biomarker of exposure to environmental VOCs." @default.
• W1993702997 created "2016-06-24" @default.
• W1993702997 creator A5030102122 @default.
• W1993702997 creator A5043136683 @default.
• W1993702997 creator A5044233050 @default.
• W1993702997 creator A5053187525 @default.
• W1993702997 creator A5067425795 @default.
• W1993702997 creator A5074088882 @default.
• W1993702997 creator A5084954751 @default.
• W1993702997 date "2002-08-01" @default.
• W1993702997 modified "2023-10-11" @default.
• W1993702997 title "Volatile organic compounds cytotoxicity and expression of HSP72, HSP90 and GRP78 stress proteins in cultured human cells" @default.
• W1993702997 cites W1775749144 @default.
• W1993702997 cites W1964431628 @default.
• W1993702997 cites W1967065669 @default.
• W1993702997 cites W1968060184 @default.
• W1993702997 cites W1970948278 @default.
• W1993702997 cites W1973895299 @default.
• W1993702997 cites W1979802318 @default.
• W1993702997 cites W1992549494 @default.
• W1993702997 cites W1993757992 @default.
• W1993702997 cites W1998092373 @default.
• W1993702997 cites W2012348426 @default.
• W1993702997 cites W2012894263 @default.
• W1993702997 cites W2015066946 @default.
• W1993702997 cites W2015957972 @default.
• W1993702997 cites W2020487961 @default.
• W1993702997 cites W2030020339 @default.
• W1993702997 cites W2043459592 @default.
• W1993702997 cites W2046329541 @default.
• W1993702997 cites W2058030785 @default.
• W1993702997 cites W2061569274 @default.
• W1993702997 cites W2064163665 @default.
• W1993702997 cites W2087096578 @default.
• W1993702997 cites W2088201967 @default.
• W1993702997 cites W2100837269 @default.
• W1993702997 cites W2130348414 @default.
• W1993702997 cites W2141181325 @default.
• W1993702997 cites W2149389255 @default.
• W1993702997 cites W2155664391 @default.
• W1993702997 cites W2163819445 @default.
• W1993702997 cites W3147019758 @default.
• W1993702997 cites W62793449 @default.
• W1993702997 doi "https://doi.org/10.1016/s0167-4889(02)00271-9" @default.
• W1993702997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12183065" @default.
• W1993702997 hasPublicationYear "2002" @default.
• W1993702997 type Work @default.
• W1993702997 sameAs 1993702997 @default.
• W1993702997 citedByCount "36" @default.
• W1993702997 countsByYear W19937029972012 @default.
• W1993702997 countsByYear W19937029972013 @default.
• W1993702997 countsByYear W19937029972014 @default.
• W1993702997 countsByYear W19937029972016 @default.
• W1993702997 countsByYear W19937029972017 @default.
• W1993702997 countsByYear W19937029972018 @default.
• W1993702997 countsByYear W19937029972019 @default.
• W1993702997 countsByYear W19937029972020 @default.
• W1993702997 crossrefType "journal-article" @default.
• W1993702997 hasAuthorship W1993702997A5030102122 @default.
• W1993702997 hasAuthorship W1993702997A5043136683 @default.
• W1993702997 hasAuthorship W1993702997A5044233050 @default.
• W1993702997 hasAuthorship W1993702997A5053187525 @default.
• W1993702997 hasAuthorship W1993702997A5067425795 @default.
• W1993702997 hasAuthorship W1993702997A5074088882 @default.
• W1993702997 hasAuthorship W1993702997A5084954751 @default.
• W1993702997 hasConcept C104317684 @default.
• W1993702997 hasConcept C109316439 @default.
• W1993702997 hasConcept C154317977 @default.
• W1993702997 hasConcept C158617107 @default.
• W1993702997 hasConcept C178790620 @default.
• W1993702997 hasConcept C185592680 @default.
• W1993702997 hasConcept C190283241 @default.
• W1993702997 hasConcept C202751555 @default.
• W1993702997 hasConcept C205260736 @default.
• W1993702997 hasConcept C2775932338 @default.
• W1993702997 hasConcept C2777691172 @default.
• W1993702997 hasConcept C2778142098 @default.
• W1993702997 hasConcept C2779533485 @default.
• W1993702997 hasConcept C2779896714 @default.
• W1993702997 hasConcept C2781197716 @default.
• W1993702997 hasConcept C29730261 @default.
• W1993702997 hasConcept C54355233 @default.
• W1993702997 hasConcept C55493867 @default.
• W1993702997 hasConcept C68991219 @default.
• W1993702997 hasConcept C81885089 @default.
• W1993702997 hasConcept C82685317 @default.
• W1993702997 hasConcept C86803240 @default.
• W1993702997 hasConceptScore W1993702997C104317684 @default.
• W1993702997 hasConceptScore W1993702997C109316439 @default.
• W1993702997 hasConceptScore W1993702997C154317977 @default.
• W1993702997 hasConceptScore W1993702997C158617107 @default.
• W1993702997 hasConceptScore W1993702997C178790620 @default.
• W1993702997 hasConceptScore W1993702997C185592680 @default.
• W1993702997 hasConceptScore W1993702997C190283241 @default.
• W1993702997 hasConceptScore W1993702997C202751555 @default.
• W1993702997 hasConceptScore W1993702997C205260736 @default.
• W1993702997 hasConceptScore W1993702997C2775932338 @default.
• W1993702997 hasConceptScore W1993702997C2777691172 @default.

• next