Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993711224> ?p ?o ?g. }
- W1993711224 endingPage "440" @default.
- W1993711224 startingPage "434" @default.
- W1993711224 abstract "Self assembly between cations and anions is ubiquitous throughout nature. Important biological structures such as chromatin often use polyvalent assembly between a polycation and a polyaninon. Biomedical importance of synthetic polycations arises from their affinity to polyanions such as nucleic acid and heparan sulfate. However, the limited biocompatibility of synthetic polycations hampers the realization of their immense potential. By examining biocompatible cationic peptides, we hypothesize that a biocompatible polycation should be biodegradable and made from endogenous cations. We designed an arginine-based biodegradable polycation and demonstrated that it was orders of magnitude more compatible than conventional polycations in vitro and in vivo. This biocompatibility diminishes when L-arginine is substituted with D-arginine or when the biodegradable ester linker changes to a biostable ether linker. We believe this design can lead to many biocompatible polycations that can significantly advance a wide range of applications including controlled release, tissue engineering, biosensing, and medical devices." @default.
- W1993711224 created "2016-06-24" @default.
- W1993711224 creator A5017735716 @default.
- W1993711224 creator A5037794465 @default.
- W1993711224 creator A5044490149 @default.
- W1993711224 creator A5065056595 @default.
- W1993711224 creator A5075280137 @default.
- W1993711224 date "2010-12-14" @default.
- W1993711224 modified "2023-10-08" @default.
- W1993711224 title "A Biocompatible Arginine‐Based Polycation" @default.
- W1993711224 cites W1965144118 @default.
- W1993711224 cites W1969233927 @default.
- W1993711224 cites W1979519758 @default.
- W1993711224 cites W1980042430 @default.
- W1993711224 cites W1981304130 @default.
- W1993711224 cites W1985469208 @default.
- W1993711224 cites W1997547574 @default.
- W1993711224 cites W2000200774 @default.
- W1993711224 cites W2003181279 @default.
- W1993711224 cites W2012172441 @default.
- W1993711224 cites W2017420125 @default.
- W1993711224 cites W2017952250 @default.
- W1993711224 cites W2019876924 @default.
- W1993711224 cites W2022318100 @default.
- W1993711224 cites W2028184858 @default.
- W1993711224 cites W2033021454 @default.
- W1993711224 cites W2035500216 @default.
- W1993711224 cites W2044524539 @default.
- W1993711224 cites W2045672171 @default.
- W1993711224 cites W2061497413 @default.
- W1993711224 cites W2077364459 @default.
- W1993711224 cites W2081221541 @default.
- W1993711224 cites W2081926265 @default.
- W1993711224 cites W2083624809 @default.
- W1993711224 cites W2086069830 @default.
- W1993711224 cites W2090380610 @default.
- W1993711224 cites W2090990180 @default.
- W1993711224 cites W2094714478 @default.
- W1993711224 cites W2101621191 @default.
- W1993711224 cites W2111217096 @default.
- W1993711224 cites W2114918609 @default.
- W1993711224 cites W2117208350 @default.
- W1993711224 cites W2122965729 @default.
- W1993711224 cites W2131192673 @default.
- W1993711224 cites W2162206996 @default.
- W1993711224 cites W2163371839 @default.
- W1993711224 cites W4210998540 @default.
- W1993711224 doi "https://doi.org/10.1002/adfm.201000969" @default.
- W1993711224 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3564668" @default.
- W1993711224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23393493" @default.
- W1993711224 hasPublicationYear "2010" @default.
- W1993711224 type Work @default.
- W1993711224 sameAs 1993711224 @default.
- W1993711224 citedByCount "33" @default.
- W1993711224 countsByYear W19937112242012 @default.
- W1993711224 countsByYear W19937112242014 @default.
- W1993711224 countsByYear W19937112242015 @default.
- W1993711224 countsByYear W19937112242016 @default.
- W1993711224 countsByYear W19937112242017 @default.
- W1993711224 countsByYear W19937112242018 @default.
- W1993711224 countsByYear W19937112242019 @default.
- W1993711224 countsByYear W19937112242020 @default.
- W1993711224 countsByYear W19937112242021 @default.
- W1993711224 countsByYear W19937112242023 @default.
- W1993711224 crossrefType "journal-article" @default.
- W1993711224 hasAuthorship W1993711224A5017735716 @default.
- W1993711224 hasAuthorship W1993711224A5037794465 @default.
- W1993711224 hasAuthorship W1993711224A5044490149 @default.
- W1993711224 hasAuthorship W1993711224A5065056595 @default.
- W1993711224 hasAuthorship W1993711224A5075280137 @default.
- W1993711224 hasBestOaLocation W19937112242 @default.
- W1993711224 hasConcept C111919701 @default.
- W1993711224 hasConcept C12554922 @default.
- W1993711224 hasConcept C1318750 @default.
- W1993711224 hasConcept C136229726 @default.
- W1993711224 hasConcept C171250308 @default.
- W1993711224 hasConcept C183882617 @default.
- W1993711224 hasConcept C185592680 @default.
- W1993711224 hasConcept C188027245 @default.
- W1993711224 hasConcept C191897082 @default.
- W1993711224 hasConcept C192562407 @default.
- W1993711224 hasConcept C21951064 @default.
- W1993711224 hasConcept C2777230088 @default.
- W1993711224 hasConcept C2777468819 @default.
- W1993711224 hasConcept C2780557392 @default.
- W1993711224 hasConcept C41008148 @default.
- W1993711224 hasConcept C515207424 @default.
- W1993711224 hasConcept C55493867 @default.
- W1993711224 hasConcept C71924100 @default.
- W1993711224 hasConcept C86803240 @default.
- W1993711224 hasConceptScore W1993711224C111919701 @default.
- W1993711224 hasConceptScore W1993711224C12554922 @default.
- W1993711224 hasConceptScore W1993711224C1318750 @default.
- W1993711224 hasConceptScore W1993711224C136229726 @default.
- W1993711224 hasConceptScore W1993711224C171250308 @default.
- W1993711224 hasConceptScore W1993711224C183882617 @default.
- W1993711224 hasConceptScore W1993711224C185592680 @default.
- W1993711224 hasConceptScore W1993711224C188027245 @default.