FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993715252> ?p ?o ?g. }

• W1993715252 endingPage "410" @default.
• W1993715252 startingPage "403" @default.
• W1993715252 abstract "Reactive oxygen species participate in the pathogenesis of inflammatory airway diseases, in which increased arginase may play a role by interfering with nitric oxide (NO) synthesis and providing substrate for collagen synthesis. Therefore a modulatory role of reactive oxygen species for arginase was explored in alveolar macrophages using the NADPH oxidase inhibitor apocynin. The effects of lipopolysacharides (LPS) and apocynin on nitrite accumulation, arginase activity and mRNA for inducible NO synthase (iNOS), arginase I and II were determined. Superoxide anion (O2−) release was analysed by the iodonitrotetrazolium (INT) formazan assay. LPS (1 μg/ml) caused a 55%, transient increase in INT formation, i.e. O2− release which was inhibited by apocynin (500 μM). LPS caused a 2 fold increase in arginase activity and a marked increase in mRNA encoding arginase I, the predominant isoenzyme. Both effects were largely attenuated by apocynin. Apocynin did not affect the stability of arginase I mRNA, but accelerated the decline of arginase activity when protein synthesis was inhibited by cycloheximide. Apocynin also reduced LPS-induced nitrite accumulation (by 30%) and iNOS mRNA expression, but the magnitude of these effects was smaller than that on arginase I. Arginase I mRNA was also increased following exposure to hydrogen peroxide (H2O2, 200 μM). In conclusion, inhibition of NADPH oxidase in alveolar macrophages causes down-regulation of arginase, indicating that reactive oxygen species exert stimulatory effects on arginase. Enhanced transcription of arginase mRNA and prolongation of the life time of the active enzyme appear to contribute to the enhanced arginase activity." @default.
• W1993715252 created "2016-06-24" @default.
• W1993715252 creator A5027245710 @default.
• W1993715252 creator A5043126037 @default.
• W1993715252 creator A5055347503 @default.
• W1993715252 creator A5056060942 @default.
• W1993715252 creator A5081425109 @default.
• W1993715252 date "2008-01-01" @default.
• W1993715252 modified "2023-10-14" @default.
• W1993715252 title "Inhibition of NADPH oxidase by apocynin inhibits lipopolysaccharide (LPS) induced up-regulation of arginase in rat alveolar macrophages" @default.
• W1993715252 cites W1491567812 @default.
• W1993715252 cites W1909558445 @default.
• W1993715252 cites W1969553244 @default.
• W1993715252 cites W1974726443 @default.
• W1993715252 cites W1975924701 @default.
• W1993715252 cites W1983886923 @default.
• W1993715252 cites W1985095303 @default.
• W1993715252 cites W1988170236 @default.
• W1993715252 cites W2000781818 @default.
• W1993715252 cites W2001810187 @default.
• W1993715252 cites W2003554652 @default.
• W1993715252 cites W2013561452 @default.
• W1993715252 cites W2015111649 @default.
• W1993715252 cites W2015192504 @default.
• W1993715252 cites W2018168922 @default.
• W1993715252 cites W2022727685 @default.
• W1993715252 cites W2022735145 @default.
• W1993715252 cites W2028177209 @default.
• W1993715252 cites W2031740315 @default.
• W1993715252 cites W2031879343 @default.
• W1993715252 cites W2033601159 @default.
• W1993715252 cites W2035860876 @default.
• W1993715252 cites W2036160471 @default.
• W1993715252 cites W2044803705 @default.
• W1993715252 cites W2054510493 @default.
• W1993715252 cites W2057650318 @default.
• W1993715252 cites W2058403295 @default.
• W1993715252 cites W2059343860 @default.
• W1993715252 cites W2061276553 @default.
• W1993715252 cites W2071705315 @default.
• W1993715252 cites W2078796742 @default.
• W1993715252 cites W2080722863 @default.
• W1993715252 cites W2091675805 @default.
• W1993715252 cites W2091903267 @default.
• W1993715252 cites W2094843670 @default.
• W1993715252 cites W2098171133 @default.
• W1993715252 cites W2104984452 @default.
• W1993715252 cites W2117149723 @default.
• W1993715252 cites W2121954647 @default.
• W1993715252 cites W2125382956 @default.
• W1993715252 cites W2127823826 @default.
• W1993715252 cites W2136326878 @default.
• W1993715252 cites W2138249981 @default.
• W1993715252 cites W2142530497 @default.
• W1993715252 cites W2142917880 @default.
• W1993715252 cites W2147974982 @default.
• W1993715252 cites W2152550693 @default.
• W1993715252 cites W2419604885 @default.
• W1993715252 cites W4237308814 @default.
• W1993715252 cites W4322388707 @default.
• W1993715252 doi "https://doi.org/10.1016/j.ejphar.2007.10.043" @default.
• W1993715252 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18001708" @default.
• W1993715252 hasPublicationYear "2008" @default.
• W1993715252 type Work @default.
• W1993715252 sameAs 1993715252 @default.
• W1993715252 citedByCount "26" @default.
• W1993715252 countsByYear W19937152522012 @default.
• W1993715252 countsByYear W19937152522013 @default.
• W1993715252 countsByYear W19937152522014 @default.
• W1993715252 countsByYear W19937152522016 @default.
• W1993715252 countsByYear W19937152522017 @default.
• W1993715252 countsByYear W19937152522019 @default.
• W1993715252 countsByYear W19937152522021 @default.
• W1993715252 crossrefType "journal-article" @default.
• W1993715252 hasAuthorship W1993715252A5027245710 @default.
• W1993715252 hasAuthorship W1993715252A5043126037 @default.
• W1993715252 hasAuthorship W1993715252A5055347503 @default.
• W1993715252 hasAuthorship W1993715252A5056060942 @default.
• W1993715252 hasAuthorship W1993715252A5081425109 @default.
• W1993715252 hasConcept C153911025 @default.
• W1993715252 hasConcept C164007495 @default.
• W1993715252 hasConcept C178790620 @default.
• W1993715252 hasConcept C181199279 @default.
• W1993715252 hasConcept C185592680 @default.
• W1993715252 hasConcept C2776179834 @default.
• W1993715252 hasConcept C2776384668 @default.
• W1993715252 hasConcept C2777209548 @default.
• W1993715252 hasConcept C2777468819 @default.
• W1993715252 hasConcept C2777622882 @default.
• W1993715252 hasConcept C2779719074 @default.
• W1993715252 hasConcept C2780795997 @default.
• W1993715252 hasConcept C48349386 @default.
• W1993715252 hasConcept C515207424 @default.
• W1993715252 hasConcept C519581460 @default.
• W1993715252 hasConcept C55493867 @default.
• W1993715252 hasConcept C86803240 @default.
• W1993715252 hasConceptScore W1993715252C153911025 @default.
• W1993715252 hasConceptScore W1993715252C164007495 @default.

• next