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- W1993733404 abstract "Findings consistent with the diagnosis of acute intermittent porphyria developed in a patient with primary aldosteronism. Although these two diseases probably arise independently, they may be inter-related. It is well documented that certain steroid hormones can cause exacerbations of acute intermittent porphyria. This is presumably due to stimulation of aminolevulinic acid (ALA) synthetase, which is the enzyme in the rate-limiting first step of the porphyrin-heme pathway. All the steroids with strong porphyria-inducing activity share the 5β-hydrogen (A:B cis) configuration. Although aldosterone lacks the 5β-hydrogen, its major metabolite, tetrahydroaldosterone, does not. This metabolite of aldosterone may be active in induction of ALA-synthetase. Since removal of the aldosteronoma, the patient has had two attacks of porphyria and continues to have mild hypertension." @default.
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- W1993733404 date "1971-09-09" @default.
- W1993733404 modified "2023-09-25" @default.
- W1993733404 title "Primary Aldosteronism Associated with Acute Intermittent Porphyria" @default.
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- W1993733404 doi "https://doi.org/10.1056/nejm197109092851102" @default.
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