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- W1993735601 abstract "Abstract Less than four years ago, the sudden appearance of parkinsonian symptoms in young drug abusers was traced to the presence of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) in carelessly synthesized batches of ‘new heroin', an illicit pethidine analog. The world-wide interest and intense research effort this discovery generated has resulted in the identification of the enzymes involved in the conversion of MPTP to the neurotoxic form. It has also elucidated the crucial roles played by the dopamine reuptake system, by a newly discovered mitochondrial carrier, and by mitochondrial NADH dehydrogenase, the ultimate target, in the destruction of the nigrostriatal cells of the brain." @default.
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- W1993735601 date "1987-01-01" @default.
- W1993735601 modified "2023-09-27" @default.
- W1993735601 title "Biochemistry of the neurotoxic action of MPTP: or how a faulty batch of ‘designer drug’ led to parkinsonism in drug abusers" @default.
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- W1993735601 doi "https://doi.org/10.1016/0968-0004(87)90132-0" @default.
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