Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993744650> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W1993744650 endingPage "357" @default.
- W1993744650 startingPage "354" @default.
- W1993744650 abstract "Coronary collateral development in response to chronic myocardial ischemia is modulated by the integrated release of a variety of growth factors. Protamine, a specific inhibitor of angiogenesis in vitro and in vivo, may attenuate coronary collateral development. The purpose of this investigation was to characterize a model of canine coronary collateral development and to ascertain the effects of protamine on collateral perfusion in response to chronic myocardial ischemia. Ischemia-induced coronary collateral enhancement in response to daily, repetitive, 2-minute left anterior descending (LAD) coronary artery occlusions over 22 consecutive days was demonstrated in control (saline treated) dogs by time dependent, significant (p < 0.05) increases in collateral blood flow to ischemic myocardium. Concomitant with increases in collateral perfusion, myocardial contractile function during LAD occlusion was progressively normalized, and percent coronary flow repayment was reduced successively. These indicators of collateral development were attenuated significantly by administration of subcutaneous protamine. The present findings demonstrate that a model of brief, repetitive, coronary artery occlusion in chronically instrumented dogs sensitively elicits extensive enhancement of the coronary collateral circulation in response to chronic myocardial ischemia. In contrast, protamine attenuates coronary collateral development through its actions as an inhibitor of angiogenesis." @default.
- W1993744650 created "2016-06-24" @default.
- W1993744650 creator A5061563909 @default.
- W1993744650 creator A5088751909 @default.
- W1993744650 date "1995-07-01" @default.
- W1993744650 modified "2023-09-23" @default.
- W1993744650 title "Modulation of Coronary Collateral Angiogenesis: A Canine Model of Neovascularization Induced by Chronic Ischemia" @default.
- W1993744650 cites W1972855766 @default.
- W1993744650 cites W1972908581 @default.
- W1993744650 cites W1980408417 @default.
- W1993744650 cites W2026598761 @default.
- W1993744650 cites W2067509664 @default.
- W1993744650 cites W2074116596 @default.
- W1993744650 cites W2076485836 @default.
- W1993744650 cites W2077840438 @default.
- W1993744650 cites W2085738449 @default.
- W1993744650 cites W2112481821 @default.
- W1993744650 cites W2142401146 @default.
- W1993744650 cites W2162740250 @default.
- W1993744650 cites W4250806706 @default.
- W1993744650 doi "https://doi.org/10.1111/j.1540-8191.1995.tb00623.x" @default.
- W1993744650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7549194" @default.
- W1993744650 hasPublicationYear "1995" @default.
- W1993744650 type Work @default.
- W1993744650 sameAs 1993744650 @default.
- W1993744650 citedByCount "5" @default.
- W1993744650 countsByYear W19937446502017 @default.
- W1993744650 crossrefType "journal-article" @default.
- W1993744650 hasAuthorship W1993744650A5061563909 @default.
- W1993744650 hasAuthorship W1993744650A5088751909 @default.
- W1993744650 hasBestOaLocation W19937446501 @default.
- W1993744650 hasConcept C126322002 @default.
- W1993744650 hasConcept C146957229 @default.
- W1993744650 hasConcept C158846371 @default.
- W1993744650 hasConcept C164705383 @default.
- W1993744650 hasConcept C2776157398 @default.
- W1993744650 hasConcept C2776599846 @default.
- W1993744650 hasConcept C2777557582 @default.
- W1993744650 hasConcept C2780393670 @default.
- W1993744650 hasConcept C2780394083 @default.
- W1993744650 hasConcept C2780835560 @default.
- W1993744650 hasConcept C500558357 @default.
- W1993744650 hasConcept C541997718 @default.
- W1993744650 hasConcept C71924100 @default.
- W1993744650 hasConceptScore W1993744650C126322002 @default.
- W1993744650 hasConceptScore W1993744650C146957229 @default.
- W1993744650 hasConceptScore W1993744650C158846371 @default.
- W1993744650 hasConceptScore W1993744650C164705383 @default.
- W1993744650 hasConceptScore W1993744650C2776157398 @default.
- W1993744650 hasConceptScore W1993744650C2776599846 @default.
- W1993744650 hasConceptScore W1993744650C2777557582 @default.
- W1993744650 hasConceptScore W1993744650C2780393670 @default.
- W1993744650 hasConceptScore W1993744650C2780394083 @default.
- W1993744650 hasConceptScore W1993744650C2780835560 @default.
- W1993744650 hasConceptScore W1993744650C500558357 @default.
- W1993744650 hasConceptScore W1993744650C541997718 @default.
- W1993744650 hasConceptScore W1993744650C71924100 @default.
- W1993744650 hasIssue "4" @default.
- W1993744650 hasLocation W19937446501 @default.
- W1993744650 hasLocation W19937446502 @default.
- W1993744650 hasOpenAccess W1993744650 @default.
- W1993744650 hasPrimaryLocation W19937446501 @default.
- W1993744650 hasRelatedWork W1974861281 @default.
- W1993744650 hasRelatedWork W1986613486 @default.
- W1993744650 hasRelatedWork W1993699569 @default.
- W1993744650 hasRelatedWork W2070876793 @default.
- W1993744650 hasRelatedWork W2094662258 @default.
- W1993744650 hasRelatedWork W2105242227 @default.
- W1993744650 hasRelatedWork W2413229990 @default.
- W1993744650 hasRelatedWork W2415742394 @default.
- W1993744650 hasRelatedWork W2435960434 @default.
- W1993744650 hasRelatedWork W848101576 @default.
- W1993744650 hasVolume "10" @default.
- W1993744650 isParatext "false" @default.
- W1993744650 isRetracted "false" @default.
- W1993744650 magId "1993744650" @default.
- W1993744650 workType "article" @default.