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- W1993745789 abstract "Development of cell delivery platforms have been driven based on an empirical cytoprotective design. While cell-matrix and cell–cell interactions that influence biochemical effects beyond survival has been limited and overshadowed in an effort to incrementally improve biomimicking properties of the tissue-engineered constructs. Here we demonstrate fabrication of a shape controlled 3D type-I collagen-based microgel platform that can be tuned to modulate angiogenic paracrine- ‘angiocrine’ responses of human mesenchymal stem cells (hMSCs). Furthermore, these microgels were characterized as a 3D cell culture tool to assess optimal biological response as a function of cell-matrix and cell–cell interactions. Finally, optimised hMSC embedded microgels were shown to induce vascular repair and functional improvement in vivo in a mouse model of hind-limb ischemia. The approach described here in designing a tuneable cell delivery platform using naturally occurring extracellular matrix molecules highlights the need for highly customised matrices with an array of self-assembling proteins that dictate specific cell function resembling the native tissue of interest for repair." @default.
- W1993745789 created "2016-06-24" @default.
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- W1993745789 date "2014-10-01" @default.
- W1993745789 modified "2023-10-03" @default.
- W1993745789 title "A shape-controlled tuneable microgel platform to modulate angiogenic paracrine responses in stem cells" @default.
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- W1993745789 doi "https://doi.org/10.1016/j.biomaterials.2014.06.053" @default.
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