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• W1993752158 abstract "Though different in their aetiology, autism spectrum disorder (ASD), Rett syndrome (RTT) and Down syndrome (DS) are three neurodevelopmental disorders sharing significant clinical and neuropathological overlaps. Genome-wide expression studies are reviewed and available datasets from post-mortem brains reanalyzed to identify genes and gene pathways dysregulated in all three disorders. Our results surprisingly converge upon immune, and not neurodevelopmental genes, as the most consistently shared abnormality in genome-wide expression patterns. A dysregulated immune response, accompanied by enhanced oxidative stress and abnormal mitochondrial metabolism seemingly represents the common molecular underpinning of these neurodevelopmental disorders. This conclusion may be important for the definition of pharmacological therapies able to ameliorate clinical symptoms across these disorders." @default.
• W1993752158 created "2016-06-24" @default.
• W1993752158 creator A5039137482 @default.
• W1993752158 creator A5043817668 @default.
• W1993752158 creator A5086216827 @default.
• W1993752158 date "2012-01-01" @default.
• W1993752158 modified "2023-10-12" @default.
• W1993752158 title "Genome-wide expression studies in Autism spectrum disorder, Rett syndrome, and Down syndrome" @default.
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• W1993752158 doi "https://doi.org/10.1016/j.nbd.2010.11.010" @default.
• W1993752158 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21130877" @default.
• W1993752158 hasPublicationYear "2012" @default.
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