FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993756843> ?p ?o ?g. }

• W1993756843 endingPage "121" @default.
• W1993756843 startingPage "111" @default.
• W1993756843 abstract "Human topoisomerase I (topo I) is an essential cellular enzyme that relaxes DNA supercoiling. The 6.3 kDa C-terminal domain of topo I contains the active site tyrosine (Tyr723) but lacks enzymatic activity by itself. Activity can be fully reconstituted when the C-terminal domain is associated with the 56 kDa core domain. Even though several crystal structures of topo I/DNA complexes are available, crystal structures of the free topo I protein or its individual domain fragments have been difficult to obtain. In this report we analyze the human topo I C-terminal domain structure using a variety of biophysical methods. Our results indicate that this fragment protein (topo6.3) appears to be in a molten globule state. It appears to have a native-like tertiary fold that contains a large population of alpha-helix secondary structure and extensive surface hydrophobic regions. Topo6.3 is known to be readily activated with the association of the topo I core domain, and the molten globule state of topo6.3 is likely to be an energy-favorable conformation for the free topo I C-terminal domain protein. The structural fluctuation and plasticity may represent an efficient mechanism in the topo I functional pathway, where the flexibility aids in the complementary association with the core domain and in the formation of a fully productive topo I complex." @default.
• W1993756843 created "2016-06-24" @default.
• W1993756843 creator A5048808165 @default.
• W1993756843 creator A5060920580 @default.
• W1993756843 creator A5084329995 @default.
• W1993756843 creator A5091552674 @default.
• W1993756843 date "2007-07-01" @default.
• W1993756843 modified "2023-09-30" @default.
• W1993756843 title "Human topoisomerase I C-terminal domain fragment containing the active site tyrosine is a molten globule: Implication for the formation of competent productive complex" @default.
• W1993756843 cites W1871475547 @default.
• W1993756843 cites W1965127482 @default.
• W1993756843 cites W1966427792 @default.
• W1993756843 cites W1966886639 @default.
• W1993756843 cites W1969517561 @default.
• W1993756843 cites W1974853420 @default.
• W1993756843 cites W1989076564 @default.
• W1993756843 cites W1993417607 @default.
• W1993756843 cites W1994101309 @default.
• W1993756843 cites W2006424757 @default.
• W1993756843 cites W2006758809 @default.
• W1993756843 cites W2007232880 @default.
• W1993756843 cites W2021994993 @default.
• W1993756843 cites W2031733136 @default.
• W1993756843 cites W2038692006 @default.
• W1993756843 cites W2046712651 @default.
• W1993756843 cites W2049598343 @default.
• W1993756843 cites W2054553718 @default.
• W1993756843 cites W2056382700 @default.
• W1993756843 cites W2057570623 @default.
• W1993756843 cites W2063006759 @default.
• W1993756843 cites W2063067093 @default.
• W1993756843 cites W2067332276 @default.
• W1993756843 cites W2072546473 @default.
• W1993756843 cites W2077135138 @default.
• W1993756843 cites W2084038850 @default.
• W1993756843 cites W2088848851 @default.
• W1993756843 cites W2091916149 @default.
• W1993756843 cites W2092153867 @default.
• W1993756843 cites W2095512917 @default.
• W1993756843 cites W2100113089 @default.
• W1993756843 cites W2103529174 @default.
• W1993756843 cites W2107276905 @default.
• W1993756843 cites W2107876005 @default.
• W1993756843 cites W2114522205 @default.
• W1993756843 cites W2131543568 @default.
• W1993756843 cites W2131572146 @default.
• W1993756843 cites W2132600317 @default.
• W1993756843 cites W2134661315 @default.
• W1993756843 cites W2137170709 @default.
• W1993756843 cites W2141660716 @default.
• W1993756843 cites W2145538573 @default.
• W1993756843 cites W2149565889 @default.
• W1993756843 cites W2152812953 @default.
• W1993756843 cites W2157460862 @default.
• W1993756843 cites W2159921901 @default.
• W1993756843 cites W4236530034 @default.
• W1993756843 cites W865467657 @default.
• W1993756843 doi "https://doi.org/10.1016/j.jsb.2007.03.001" @default.
• W1993756843 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1993844" @default.
• W1993756843 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17434318" @default.
• W1993756843 hasPublicationYear "2007" @default.
• W1993756843 type Work @default.
• W1993756843 sameAs 1993756843 @default.
• W1993756843 citedByCount "6" @default.
• W1993756843 countsByYear W19937568432013 @default.
• W1993756843 countsByYear W19937568432016 @default.
• W1993756843 countsByYear W19937568432019 @default.
• W1993756843 crossrefType "journal-article" @default.
• W1993756843 hasAuthorship W1993756843A5048808165 @default.
• W1993756843 hasAuthorship W1993756843A5060920580 @default.
• W1993756843 hasAuthorship W1993756843A5084329995 @default.
• W1993756843 hasAuthorship W1993756843A5091552674 @default.
• W1993756843 hasBestOaLocation W19937568432 @default.
• W1993756843 hasConcept C118493188 @default.
• W1993756843 hasConcept C12554922 @default.
• W1993756843 hasConcept C134306372 @default.
• W1993756843 hasConcept C144024400 @default.
• W1993756843 hasConcept C147897179 @default.
• W1993756843 hasConcept C149923435 @default.
• W1993756843 hasConcept C181199279 @default.
• W1993756843 hasConcept C185592680 @default.
• W1993756843 hasConcept C2908647359 @default.
• W1993756843 hasConcept C33923547 @default.
• W1993756843 hasConcept C36503486 @default.
• W1993756843 hasConcept C47701112 @default.
• W1993756843 hasConcept C552990157 @default.
• W1993756843 hasConcept C55493867 @default.
• W1993756843 hasConcept C71240020 @default.
• W1993756843 hasConcept C8010536 @default.
• W1993756843 hasConcept C86803240 @default.
• W1993756843 hasConceptScore W1993756843C118493188 @default.
• W1993756843 hasConceptScore W1993756843C12554922 @default.
• W1993756843 hasConceptScore W1993756843C134306372 @default.
• W1993756843 hasConceptScore W1993756843C144024400 @default.
• W1993756843 hasConceptScore W1993756843C147897179 @default.
• W1993756843 hasConceptScore W1993756843C149923435 @default.
• W1993756843 hasConceptScore W1993756843C181199279 @default.
• W1993756843 hasConceptScore W1993756843C185592680 @default.

• next