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- W1993759747 abstract "Human fetal substantia nigra tissue, obtained following therapeutic termination of first trimester pregnancies, was grafted to cavities overlying the striatum in ciclosporin-treated rats whose nigrostriatal dopamine system had been removed unilaterally by 6-hydroxydopamine. Tyrosine hydroxylase (TH) immunocytochemistry revealed large numbers of surviving human substantia nigra neurons that matured and formed TH-positive nerve fibers reinnervating the host rat striatum. Apomorphine-induced rotational behavior in grafted animals was reduced by 70–80% in optimal cases 3–5 months after grafting. Thus human fetal dopamine neurons can correct functional deficits in dopamine-denervated rat hosts." @default.
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- W1993759747 date "1986-11-01" @default.
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- W1993759747 title "Human fetal substantia nigra grafted to the dopamine-denervated striatum of immunosuppressed rats: evidence for functional reinnervation" @default.
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- W1993759747 doi "https://doi.org/10.1016/0304-3940(86)90632-4" @default.
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