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- W1993760706 abstract "We review the findings of Cho et al.(1) on the crystal structure of a p53 tumor suppressor-DNA complex. The core DNA binding domain of p53 folds into a structure termed a β-sandwich, which organizes two loops and a loop-sheet-helix structure on one surface of p53 to interact with the consensus DNA recognition sequence of p53. These structures help to explain the functions of wild-type p53 and the effects of tumor-associated mutations on p53 DNA binding, transactivation and suppression of cellular proliferation." @default.
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- W1993760706 date "1995-01-01" @default.
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- W1993760706 title "Giant leap for p53, small step for drug design" @default.
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- W1993760706 doi "https://doi.org/10.1002/bies.950170103" @default.
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