FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993767023> ?p ?o ?g. }

• W1993767023 endingPage "19730" @default.
• W1993767023 startingPage "19725" @default.
• W1993767023 abstract "Multiple phosphorylation of β-catenin by glycogen synthase kinase 3 (GSK3) in the Wnt pathway is primed by CK1 through phosphorylation of Ser-45, which lacks a typical CK1 canonical sequence. Synthetic peptides encompassing amino acids 38–64 of β-catenin are phosphorylated by CK1 on Ser-45 with low affinity ( K m ≈1 mM), whereas intact β-catenin is phosphorylated at Ser-45 with very high affinity ( K m ≈200 nM). Peptides extended to include a putative CK1 docking motif (FXXXF) at 70–74 positions or a F74AA mutation in full-length β-catenin had no significant effect on CK1 phosphorylation efficiency. β-Catenin C-terminal deletion mutants up to residue 181 maintained their high affinity, whereas removal of the 131–181 fragment, corresponding to the first armadillo repeat, was deleterious, resulting in a 50-fold increase in K m value. Implication of the first armadillo repeat in β-catenin targeting by CK1 is supported in that the Y142E mutation, which mimics phosphorylation of Tyr-142 by tyrosine kinases and promotes dissociation of β-catenin from α-catenin, further improves CK1 phosphorylation efficiency, lowering the K m value to <50 nM, approximating the physiological concentration of β-catenin. In contrast, α-catenin, which interacts with the N - terminal region of β-catenin, prevents Ser-45 phosphorylation of CK1 in a dose-dependent manner. Our data show that the integrity of the N-terminal region and the first armadillo repeat are necessary and sufficient for high-affinity phosphorylation by CK1 of Ser-45. They also suggest that β-catenin association with α-catenin and β-catenin phosphorylation by CK1 at Ser-45 are mutually exclusive." @default.
• W1993767023 created "2016-06-24" @default.
• W1993767023 creator A5032017828 @default.
• W1993767023 creator A5041064105 @default.
• W1993767023 creator A5043254920 @default.
• W1993767023 creator A5059968730 @default.
• W1993767023 creator A5070686410 @default.
• W1993767023 creator A5089310671 @default.
• W1993767023 date "2006-12-26" @default.
• W1993767023 modified "2023-10-18" @default.
• W1993767023 title "The first armadillo repeat is involved in the recognition and regulation of β-catenin phosphorylation by protein kinase CK1" @default.
• W1993767023 cites W1524457844 @default.
• W1993767023 cites W1527579401 @default.
• W1993767023 cites W1586431212 @default.
• W1993767023 cites W1606695388 @default.
• W1993767023 cites W1866820856 @default.
• W1993767023 cites W1966291495 @default.
• W1993767023 cites W1974495707 @default.
• W1993767023 cites W1984142065 @default.
• W1993767023 cites W1986235144 @default.
• W1993767023 cites W1995532233 @default.
• W1993767023 cites W1996984755 @default.
• W1993767023 cites W1998551458 @default.
• W1993767023 cites W2005865365 @default.
• W1993767023 cites W2008221746 @default.
• W1993767023 cites W2010537141 @default.
• W1993767023 cites W2013394636 @default.
• W1993767023 cites W2013417617 @default.
• W1993767023 cites W2014460650 @default.
• W1993767023 cites W2017278109 @default.
• W1993767023 cites W2017282805 @default.
• W1993767023 cites W2017862163 @default.
• W1993767023 cites W2018348035 @default.
• W1993767023 cites W2018982558 @default.
• W1993767023 cites W2020712616 @default.
• W1993767023 cites W2024076463 @default.
• W1993767023 cites W2025187621 @default.
• W1993767023 cites W2030205108 @default.
• W1993767023 cites W2030262696 @default.
• W1993767023 cites W2031684566 @default.
• W1993767023 cites W2033106726 @default.
• W1993767023 cites W2039684616 @default.
• W1993767023 cites W2040942754 @default.
• W1993767023 cites W2047392037 @default.
• W1993767023 cites W2047666682 @default.
• W1993767023 cites W2050133045 @default.
• W1993767023 cites W2050642264 @default.
• W1993767023 cites W2055313162 @default.
• W1993767023 cites W2064862065 @default.
• W1993767023 cites W2066531752 @default.
• W1993767023 cites W2067633308 @default.
• W1993767023 cites W2069992321 @default.
• W1993767023 cites W2071458103 @default.
• W1993767023 cites W2072742856 @default.
• W1993767023 cites W2075319861 @default.
• W1993767023 cites W2076809067 @default.
• W1993767023 cites W2077706533 @default.
• W1993767023 cites W2102600746 @default.
• W1993767023 cites W2114511731 @default.
• W1993767023 cites W2118870612 @default.
• W1993767023 cites W2124008135 @default.
• W1993767023 cites W2135067095 @default.
• W1993767023 cites W2135279930 @default.
• W1993767023 cites W2142493853 @default.
• W1993767023 cites W2148002384 @default.
• W1993767023 cites W2159738116 @default.
• W1993767023 cites W2161465643 @default.
• W1993767023 cites W2170678561 @default.
• W1993767023 doi "https://doi.org/10.1073/pnas.0609424104" @default.
• W1993767023 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1750875" @default.
• W1993767023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17172446" @default.
• W1993767023 hasPublicationYear "2006" @default.
• W1993767023 type Work @default.
• W1993767023 sameAs 1993767023 @default.
• W1993767023 citedByCount "41" @default.
• W1993767023 countsByYear W19937670232012 @default.
• W1993767023 countsByYear W19937670232013 @default.
• W1993767023 countsByYear W19937670232014 @default.
• W1993767023 countsByYear W19937670232015 @default.
• W1993767023 countsByYear W19937670232016 @default.
• W1993767023 countsByYear W19937670232018 @default.
• W1993767023 countsByYear W19937670232019 @default.
• W1993767023 countsByYear W19937670232020 @default.
• W1993767023 countsByYear W19937670232021 @default.
• W1993767023 countsByYear W19937670232022 @default.
• W1993767023 countsByYear W19937670232023 @default.
• W1993767023 crossrefType "journal-article" @default.
• W1993767023 hasAuthorship W1993767023A5032017828 @default.
• W1993767023 hasAuthorship W1993767023A5041064105 @default.
• W1993767023 hasAuthorship W1993767023A5043254920 @default.
• W1993767023 hasAuthorship W1993767023A5059968730 @default.
• W1993767023 hasAuthorship W1993767023A5070686410 @default.
• W1993767023 hasAuthorship W1993767023A5089310671 @default.
• W1993767023 hasBestOaLocation W19937670231 @default.
• W1993767023 hasConcept C11960822 @default.
• W1993767023 hasConcept C137620995 @default.
• W1993767023 hasConcept C139489369 @default.
• W1993767023 hasConcept C153911025 @default.

• next