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• W1993767935 endingPage "331" @default.
• W1993767935 startingPage "317" @default.
• W1993767935 abstract "The ultrastructural characteristics of liver progenitor cell types of human atypical ductular reactions seen in chronic cholestasis, in regenerating human liver after submassive necrosis, in alcoholic liver disease, and in focal nodular hyperplasia are compared with liver progenitor cell types seen during experimental cholangiocarcinogenesis in hamsters; during hepatocarcinogenesis in rats; and in response to periportal liver injury induced by allyl alcohol in rats. Three types of progenitor cells have been identified in human atypical ductular reactions: type I: primitive, has an oval shape, marginal chromatin, few cellular organelles, rare tonofilaments, and forms desmosomal junctions with adjacent liver cells; type II: bile duct–like, is located within ducts, has few organelles, and forms lateral membrane interdigitations with other duct-like cells; and type III: hepatocyte-like, is located in hepatic cords, forms a bile canaliculus, has tight junctions with other hepatocyte-like cells, prominent mitochondria and rough endoplasmic reticulum, and some have lysosomes and a poorly developed Golgi apparatus. Each type is seen during cholangiocarcinogenesis in hamsters, but the most prominent cell type is type II, duct-like. A more primitive cell type (“type 0 cell”), as well as type I cells, are seen in the intraportal zone of the liver within 1 to 2 days after carcinogen exposure or periportal injury in the rat, but both type II and type III are seen later as the progenitor cells expand into the liver lobule. After allyl alcohol injury, type 0 cells precede the appearance of type I and type III cells, but most of the cells that span the periportal necrotic zone are type III hepatocyte-like cells showing different degrees of hepatocytic differentiation. Some type II cells are also seen, but these are essentially limited to ducts. It is concluded that there is a primitive stem cell type in the liver (type 0) that may differentiate directly into type I and then into type II, duct-like or or type III hepatocyte-like cells. The terms oval cell, transitional hepatocyte, biliary hepatocyte, hepatocyte-like cell, atypical ductular cell, neocholangiole, etc., are used to describe these cells. Although these terms are useful as general descriptive terms for liver precursor cells at the light microscopic level, the cells included in these descriptive categories may be very different from one another biologically and ultrastructurally." @default.
• W1993767935 created "2016-06-24" @default.
• W1993767935 creator A5090632544 @default.
• W1993767935 date "1998-02-01" @default.
• W1993767935 modified "2023-10-15" @default.
• W1993767935 title "Comparison of liver progenitor cells in human atypical ductular reactions with those seen in experimental models of liver injury" @default.
• W1993767935 cites W1826566192 @default.
• W1993767935 cites W1929234178 @default.
• W1993767935 cites W1967440651 @default.
• W1993767935 cites W1968015546 @default.
• W1993767935 cites W1971664569 @default.
• W1993767935 cites W1973518385 @default.
• W1993767935 cites W1973604928 @default.
• W1993767935 cites W1973997143 @default.
• W1993767935 cites W1974230920 @default.
• W1993767935 cites W1976332957 @default.
• W1993767935 cites W1978443737 @default.
• W1993767935 cites W1983502032 @default.
• W1993767935 cites W1986909282 @default.
• W1993767935 cites W1988329806 @default.
• W1993767935 cites W1992507333 @default.
• W1993767935 cites W1996109421 @default.
• W1993767935 cites W1998081914 @default.
• W1993767935 cites W1999197639 @default.
• W1993767935 cites W2003170300 @default.
• W1993767935 cites W2008318392 @default.
• W1993767935 cites W2010081432 @default.
• W1993767935 cites W2011048648 @default.
• W1993767935 cites W2013961488 @default.
• W1993767935 cites W2014894422 @default.
• W1993767935 cites W2017529586 @default.
• W1993767935 cites W2017842650 @default.
• W1993767935 cites W2019863642 @default.
• W1993767935 cites W2023727197 @default.
• W1993767935 cites W2025388733 @default.
• W1993767935 cites W2027469595 @default.
• W1993767935 cites W2031521660 @default.
• W1993767935 cites W2034483815 @default.
• W1993767935 cites W2035084993 @default.
• W1993767935 cites W203837051 @default.
• W1993767935 cites W2038716479 @default.
• W1993767935 cites W2038993390 @default.
• W1993767935 cites W2039415807 @default.
• W1993767935 cites W2039618230 @default.
• W1993767935 cites W2042867572 @default.
• W1993767935 cites W2043344911 @default.
• W1993767935 cites W2048716965 @default.
• W1993767935 cites W2051172626 @default.
• W1993767935 cites W2051980794 @default.
• W1993767935 cites W2052357818 @default.
• W1993767935 cites W2055565800 @default.
• W1993767935 cites W2056419765 @default.
• W1993767935 cites W2059401136 @default.
• W1993767935 cites W2060173899 @default.
• W1993767935 cites W2062101720 @default.
• W1993767935 cites W2063495563 @default.
• W1993767935 cites W2065995561 @default.
• W1993767935 cites W2066664855 @default.
• W1993767935 cites W2067571613 @default.
• W1993767935 cites W2074461807 @default.
• W1993767935 cites W2076893921 @default.
• W1993767935 cites W2081669424 @default.
• W1993767935 cites W2083581104 @default.
• W1993767935 cites W2084767118 @default.
• W1993767935 cites W2084857174 @default.
• W1993767935 cites W2090497358 @default.
• W1993767935 cites W2090540008 @default.
• W1993767935 cites W2090855121 @default.
• W1993767935 cites W2091353697 @default.
• W1993767935 cites W2093431439 @default.
• W1993767935 cites W2094050302 @default.
• W1993767935 cites W2094547107 @default.
• W1993767935 cites W2101668293 @default.
• W1993767935 cites W2107150239 @default.
• W1993767935 cites W2109971285 @default.
• W1993767935 cites W2110229128 @default.
• W1993767935 cites W2136218955 @default.
• W1993767935 cites W2139432060 @default.
• W1993767935 cites W2145980749 @default.
• W1993767935 cites W2147439248 @default.
• W1993767935 cites W2147911337 @default.
• W1993767935 cites W2157661783 @default.
• W1993767935 cites W2163494169 @default.
• W1993767935 cites W2164498029 @default.
• W1993767935 cites W2168362482 @default.
• W1993767935 cites W2169787307 @default.
• W1993767935 cites W2169994464 @default.
• W1993767935 cites W2316962700 @default.
• W1993767935 cites W2318874590 @default.
• W1993767935 cites W2320146031 @default.
• W1993767935 cites W2322385389 @default.
• W1993767935 cites W2326346059 @default.
• W1993767935 cites W2332521194 @default.
• W1993767935 cites W2521880154 @default.
• W1993767935 cites W2912986512 @default.
• W1993767935 cites W96227520 @default.
• W1993767935 doi "https://doi.org/10.1002/hep.510270202" @default.
• W1993767935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9462626" @default.

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