Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993770139> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W1993770139 endingPage "464" @default.
- W1993770139 startingPage "449" @default.
- W1993770139 abstract "Newly synthesized vanadyl-poly(gamma-glutamic acid) complex (VO-gamma-PGA) with a VO(O4) coordination mode was found to have potent antidiabetic activity in streptozotocin (STZ)-induced type 1 diabetic mice (STZ-mice), compared with that of a solution containing only vanadyl sulfate, VOSO4. This was the first example of orally active vanadyl complex of gamma-PGA for treating STZ-mice. To better define its efficacy, we examined here the effects of VO-gamma-PGA treatment in STZ-mice by oral administration at the dose of 10 mg V/kg body mass for a longer period time than our previous study. The improvement in diabetic states in STZ-mice compared with saline-treated nondiabetic normal Std ddY mice. It was found that the elevated blood glucose levels in STZ-mice significantly decreased after 3 days and sustained the normalized blood glucose level around 180-200 mg/dL (10-11.1 mM) for the last 14 days, which is close to the blood glucose levels 100-200 mg/dL (5.6-11.1 mM) in nondiabetic normal Std ddY mice. The improvement in diabetes was strongly corelated by the improvement in oral glucose tolerance ability, glycosylated hemoglobin (HbA1c) levels and blood pressure, and serum parameters. The present results confirmed that VO-gamma-PGA complex is a promising, orally active insulin-mimetic agent to treat type 1 diabetic mice." @default.
- W1993770139 created "2016-06-24" @default.
- W1993770139 creator A5024036608 @default.
- W1993770139 creator A5049208030 @default.
- W1993770139 creator A5065473510 @default.
- W1993770139 date "2007-05-10" @default.
- W1993770139 modified "2023-10-16" @default.
- W1993770139 title "Antidiabetic Activity of the Orally Effective Vanadyl-Poly (γ-Glutamic Acid) Complex in Streptozotocin(STZ)-induced Type 1 Diabetic Mice" @default.
- W1993770139 cites W1978546479 @default.
- W1993770139 cites W1989940093 @default.
- W1993770139 cites W2028146716 @default.
- W1993770139 cites W2046359028 @default.
- W1993770139 cites W2056379381 @default.
- W1993770139 cites W2056853110 @default.
- W1993770139 cites W2080786846 @default.
- W1993770139 cites W2083311703 @default.
- W1993770139 cites W2085912574 @default.
- W1993770139 cites W2086997985 @default.
- W1993770139 cites W2088092545 @default.
- W1993770139 cites W2142517644 @default.
- W1993770139 cites W2159565889 @default.
- W1993770139 cites W2460405506 @default.
- W1993770139 cites W308797770 @default.
- W1993770139 cites W4295849207 @default.
- W1993770139 doi "https://doi.org/10.1177/0885328207078067" @default.
- W1993770139 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17494957" @default.
- W1993770139 hasPublicationYear "2007" @default.
- W1993770139 type Work @default.
- W1993770139 sameAs 1993770139 @default.
- W1993770139 citedByCount "11" @default.
- W1993770139 countsByYear W19937701392012 @default.
- W1993770139 countsByYear W19937701392017 @default.
- W1993770139 countsByYear W19937701392018 @default.
- W1993770139 countsByYear W19937701392020 @default.
- W1993770139 countsByYear W19937701392021 @default.
- W1993770139 crossrefType "journal-article" @default.
- W1993770139 hasAuthorship W1993770139A5024036608 @default.
- W1993770139 hasAuthorship W1993770139A5049208030 @default.
- W1993770139 hasAuthorship W1993770139A5065473510 @default.
- W1993770139 hasConcept C126322002 @default.
- W1993770139 hasConcept C134018914 @default.
- W1993770139 hasConcept C185592680 @default.
- W1993770139 hasConcept C2777056448 @default.
- W1993770139 hasConcept C2777397205 @default.
- W1993770139 hasConcept C2777928079 @default.
- W1993770139 hasConcept C2778917026 @default.
- W1993770139 hasConcept C2779280383 @default.
- W1993770139 hasConcept C2779306644 @default.
- W1993770139 hasConcept C555293320 @default.
- W1993770139 hasConcept C71924100 @default.
- W1993770139 hasConcept C98274493 @default.
- W1993770139 hasConceptScore W1993770139C126322002 @default.
- W1993770139 hasConceptScore W1993770139C134018914 @default.
- W1993770139 hasConceptScore W1993770139C185592680 @default.
- W1993770139 hasConceptScore W1993770139C2777056448 @default.
- W1993770139 hasConceptScore W1993770139C2777397205 @default.
- W1993770139 hasConceptScore W1993770139C2777928079 @default.
- W1993770139 hasConceptScore W1993770139C2778917026 @default.
- W1993770139 hasConceptScore W1993770139C2779280383 @default.
- W1993770139 hasConceptScore W1993770139C2779306644 @default.
- W1993770139 hasConceptScore W1993770139C555293320 @default.
- W1993770139 hasConceptScore W1993770139C71924100 @default.
- W1993770139 hasConceptScore W1993770139C98274493 @default.
- W1993770139 hasIssue "5" @default.
- W1993770139 hasLocation W19937701391 @default.
- W1993770139 hasLocation W19937701392 @default.
- W1993770139 hasOpenAccess W1993770139 @default.
- W1993770139 hasPrimaryLocation W19937701391 @default.
- W1993770139 hasRelatedWork W1995071802 @default.
- W1993770139 hasRelatedWork W2003485540 @default.
- W1993770139 hasRelatedWork W2011709829 @default.
- W1993770139 hasRelatedWork W2044988659 @default.
- W1993770139 hasRelatedWork W2055342276 @default.
- W1993770139 hasRelatedWork W2095626059 @default.
- W1993770139 hasRelatedWork W2112457773 @default.
- W1993770139 hasRelatedWork W2131147582 @default.
- W1993770139 hasRelatedWork W2434287781 @default.
- W1993770139 hasRelatedWork W2748952813 @default.
- W1993770139 hasVolume "22" @default.
- W1993770139 isParatext "false" @default.
- W1993770139 isRetracted "false" @default.
- W1993770139 magId "1993770139" @default.
- W1993770139 workType "article" @default.