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• W1993774482 startingPage "R2249" @default.
• W1993774482 abstract "Prolonged or unaccustomed exercise leads to muscle cell membrane damage, detectable as release of the intracellular enzyme lactic acid dehydrogenase (LDH). This is correlated to excitation-induced influx of Ca 2+ , but it cannot be excluded that mechanical stress contributes to the damage. We here explore this question using N-benzyl- p-toluene sulfonamide (BTS), which specifically blocks muscle contraction. Extensor digitorum longus muscles were prepared from 4-wk-old rats and mounted on holders for isometric contractions. Muscles were stimulated intermittently at 40 Hz for 15–60 min or exposed to the Ca 2+ ionophore A23187. Electrical stimulation increased 45 Ca influx 3–5 fold. This was followed by a progressive release of LDH, which was correlated to the influx of Ca 2+ . BTS (50 μM) caused a 90% inhibition of contractile force but had no effect on the excitation-induced 45 Ca influx. After stimulation, ATP and creatine phosphate levels were higher in BTS-treated muscles, most likely due to the cessation of ATP-utilization for cross-bridge cycling, indicating a better energy status of these muscles. No release of LDH was observed in BTS-treated muscles. However, when exposed to anoxia, electrical stimulation caused a marked increase in LDH release that was not suppressed by BTS but associated with a decrease in the content of ATP. Dynamic passive stretching caused no increase in muscle Ca 2+ content and only a minor release of LDH, whereas treatment with A23187 markedly increased LDH release both in control and BTS-treated muscles. In conclusion, after isometric contractions, muscle cell membrane damage depends on Ca 2+ influx and energy status and not on mechanical stress." @default.
• W1993774482 created "2016-06-24" @default.
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• W1993774482 date "2007-06-01" @default.
• W1993774482 modified "2023-09-24" @default.
• W1993774482 title "Causes of excitation-induced muscle cell damage in isometric contractions: mechanical stress or calcium overload?" @default.
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• W1993774482 doi "https://doi.org/10.1152/ajpregu.00415.2006" @default.
• W1993774482 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17332163" @default.
• W1993774482 hasPublicationYear "2007" @default.
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