FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993775249> ?p ?o ?g. }

• W1993775249 endingPage "1577" @default.
• W1993775249 startingPage "1572" @default.
• W1993775249 abstract "The yeast Saccharomyces cerevisiae senses glucose through two transmembrane glucose sensors, Snf3 and Rgt2. Extracellular glucose causes these sensors to generate an intracellular signal that induces expression of HXT genes encoding glucose transporters by inhibiting the function of Rgt1, a transcriptional repressor of HXT genes. We present the following evidence that suggests that the glucose sensors are coupled to the membrane-associated protein kinase casein kinase I (Yck1). (i) Overexpression of Yck1 leads to constitutive HXT1 expression; (ii) Yck1 (or its paralogue Yck2) is required for glucose induction of HXT1 expression; (iii) Yck1 interacts with the Rgt2 glucose sensor; and (iv) attaching the C-terminal cytoplasmic tail of Rgt2 to Yck1 results in a constitutive glucose signal. The likely targets of Yck1 in this signal transduction pathway are Mth1 and Std1, which bind to and regulate function of the Rgt1 transcription factor and bind to the C-terminal cytoplasmic domain of glucose sensors. Potential casein kinase I phosphorylation sites in Mth1 and Std1 are required for normal glucose regulation of HXT1 expression, and Yck1 catalyzes phosphorylation of Mth1 and Std1 in vitro. These results support a model of glucose signaling in which glucose binding to the glucose sensors causes them to activate Yck1 in the cell membrane, which then phosphorylates Mth1 and Std1 bound to the cytoplasmic face of the glucose sensors, triggering their degradation and leading to the derepression of HXT gene expression. Our results add nutrient sensing to the growing list of processes in which casein kinase I is involved." @default.
• W1993775249 created "2016-06-24" @default.
• W1993775249 creator A5000757668 @default.
• W1993775249 creator A5042991989 @default.
• W1993775249 date "2004-01-30" @default.
• W1993775249 modified "2023-10-09" @default.
• W1993775249 title "Glucose sensing and signaling in <i>Saccharomyces cerevisiae</i> through the Rgt2 glucose sensor and casein kinase I" @default.
• W1993775249 cites W1504478980 @default.
• W1993775249 cites W1516349995 @default.
• W1993775249 cites W1517699507 @default.
• W1993775249 cites W1596414641 @default.
• W1993775249 cites W1849405398 @default.
• W1993775249 cites W1850569493 @default.
• W1993775249 cites W1934675177 @default.
• W1993775249 cites W1975985109 @default.
• W1993775249 cites W1985701155 @default.
• W1993775249 cites W1988608160 @default.
• W1993775249 cites W1994334317 @default.
• W1993775249 cites W1994670921 @default.
• W1993775249 cites W1996110479 @default.
• W1993775249 cites W2000047924 @default.
• W1993775249 cites W2034875354 @default.
• W1993775249 cites W2050642264 @default.
• W1993775249 cites W2058682865 @default.
• W1993775249 cites W2060981193 @default.
• W1993775249 cites W2096211374 @default.
• W1993775249 cites W2108599821 @default.
• W1993775249 cites W2114978834 @default.
• W1993775249 cites W2116256205 @default.
• W1993775249 cites W2118956583 @default.
• W1993775249 cites W2132387250 @default.
• W1993775249 cites W2132742567 @default.
• W1993775249 cites W2134962337 @default.
• W1993775249 cites W2140147396 @default.
• W1993775249 cites W2141392309 @default.
• W1993775249 cites W2142160977 @default.
• W1993775249 cites W2143140464 @default.
• W1993775249 cites W2146546288 @default.
• W1993775249 cites W2152231771 @default.
• W1993775249 cites W2152898249 @default.
• W1993775249 cites W2156776764 @default.
• W1993775249 cites W2157058776 @default.
• W1993775249 cites W2159036256 @default.
• W1993775249 cites W2168746922 @default.
• W1993775249 cites W2169333620 @default.
• W1993775249 cites W4249233025 @default.
• W1993775249 doi "https://doi.org/10.1073/pnas.0305901101" @default.
• W1993775249 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/341776" @default.
• W1993775249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14755054" @default.
• W1993775249 hasPublicationYear "2004" @default.
• W1993775249 type Work @default.
• W1993775249 sameAs 1993775249 @default.
• W1993775249 citedByCount "211" @default.
• W1993775249 countsByYear W19937752492012 @default.
• W1993775249 countsByYear W19937752492013 @default.
• W1993775249 countsByYear W19937752492014 @default.
• W1993775249 countsByYear W19937752492015 @default.
• W1993775249 countsByYear W19937752492016 @default.
• W1993775249 countsByYear W19937752492017 @default.
• W1993775249 countsByYear W19937752492018 @default.
• W1993775249 countsByYear W19937752492019 @default.
• W1993775249 countsByYear W19937752492020 @default.
• W1993775249 countsByYear W19937752492021 @default.
• W1993775249 countsByYear W19937752492022 @default.
• W1993775249 countsByYear W19937752492023 @default.
• W1993775249 crossrefType "journal-article" @default.
• W1993775249 hasAuthorship W1993775249A5000757668 @default.
• W1993775249 hasAuthorship W1993775249A5042991989 @default.
• W1993775249 hasBestOaLocation W19937752492 @default.
• W1993775249 hasConcept C104317684 @default.
• W1993775249 hasConcept C11960822 @default.
• W1993775249 hasConcept C134018914 @default.
• W1993775249 hasConcept C150194340 @default.
• W1993775249 hasConcept C158448853 @default.
• W1993775249 hasConcept C161573976 @default.
• W1993775249 hasConcept C184235292 @default.
• W1993775249 hasConcept C186310378 @default.
• W1993775249 hasConcept C2777576037 @default.
• W1993775249 hasConcept C2779222958 @default.
• W1993775249 hasConcept C2779306644 @default.
• W1993775249 hasConcept C55493867 @default.
• W1993775249 hasConcept C62478195 @default.
• W1993775249 hasConcept C73766848 @default.
• W1993775249 hasConcept C86803240 @default.
• W1993775249 hasConcept C89200155 @default.
• W1993775249 hasConcept C95444343 @default.
• W1993775249 hasConceptScore W1993775249C104317684 @default.
• W1993775249 hasConceptScore W1993775249C11960822 @default.
• W1993775249 hasConceptScore W1993775249C134018914 @default.
• W1993775249 hasConceptScore W1993775249C150194340 @default.
• W1993775249 hasConceptScore W1993775249C158448853 @default.
• W1993775249 hasConceptScore W1993775249C161573976 @default.
• W1993775249 hasConceptScore W1993775249C184235292 @default.
• W1993775249 hasConceptScore W1993775249C186310378 @default.
• W1993775249 hasConceptScore W1993775249C2777576037 @default.
• W1993775249 hasConceptScore W1993775249C2779222958 @default.
• W1993775249 hasConceptScore W1993775249C2779306644 @default.
• W1993775249 hasConceptScore W1993775249C55493867 @default.

• next