Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993780425> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1993780425 endingPage "2385" @default.
- W1993780425 startingPage "2377" @default.
- W1993780425 abstract "Here, we describe a novel oligonucleotide array-based transcription factor (TF) interaction assay platform that can directly identify cointeracting TF complexes following binding to their regulatory DNA elements. This platform that combines immuno-coprecipitation technology with our previously reported oligonucleotide array-based TF assay (OATFA), is named targeted immuno-coprecipitation OATFA (TIC-OATFA). We illustrate use of the system to identify interaction partners of STAT1 (signal transducer and activator of transcription proteins 1) in mouse fibroblasts. Several previously known partners of STAT1, as well as new partners, were identified by TIC-OATFA, including the upstream stimulatory factors 1 and 2 (USF1, USF2), nuclear factor of activated T cells, TATA box-binding protein, nuclear factor erythroid-derived 2, nuclear factor-kappa B, and nuclear factor 1. Both USF1 and nuclear factor-kappa B are well known to interact with STAT1, but the other five TFs are previously unreported STAT1 interaction partners. We examined interactions between one new TF, USF2, and STAT1 in detail. USF2 belongs to the group of bHLH-zip transcription factors, which in a number of diseases including cancers, has enhanced activity. In summary, a novel oligonucleotide array-based assay platform was developed and used to study interactions between STAT1 and functional TF binding partners, revealing that USF2 and potentially four other new TFs are partners of STAT1 in an IFN-γ stimulated mouse fibroblast cell line." @default.
- W1993780425 created "2016-06-24" @default.
- W1993780425 creator A5008702027 @default.
- W1993780425 creator A5017004747 @default.
- W1993780425 creator A5022350572 @default.
- W1993780425 creator A5023668199 @default.
- W1993780425 creator A5024396594 @default.
- W1993780425 creator A5047523000 @default.
- W1993780425 creator A5072389210 @default.
- W1993780425 creator A5077198827 @default.
- W1993780425 creator A5080107089 @default.
- W1993780425 date "2013-07-22" @default.
- W1993780425 modified "2023-09-25" @default.
- W1993780425 title "Construction of a novel oligonucleotide array-based transcription factor interaction assay platform and its uses for profiling STAT1 cofactors in mouse fibroblast cells" @default.
- W1993780425 cites W1990228217 @default.
- W1993780425 cites W1990316655 @default.
- W1993780425 cites W1999937233 @default.
- W1993780425 cites W2000883492 @default.
- W1993780425 cites W2012932423 @default.
- W1993780425 cites W2028953190 @default.
- W1993780425 cites W2039414815 @default.
- W1993780425 cites W2041472320 @default.
- W1993780425 cites W2058399266 @default.
- W1993780425 cites W2067181050 @default.
- W1993780425 cites W2079295092 @default.
- W1993780425 cites W2092106935 @default.
- W1993780425 cites W2093498207 @default.
- W1993780425 cites W2107103504 @default.
- W1993780425 cites W2110720974 @default.
- W1993780425 cites W2111017231 @default.
- W1993780425 cites W2121458987 @default.
- W1993780425 cites W2123063659 @default.
- W1993780425 cites W2145012483 @default.
- W1993780425 cites W2154393492 @default.
- W1993780425 doi "https://doi.org/10.1002/pmic.201200521" @default.
- W1993780425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23749757" @default.
- W1993780425 hasPublicationYear "2013" @default.
- W1993780425 type Work @default.
- W1993780425 sameAs 1993780425 @default.
- W1993780425 citedByCount "2" @default.
- W1993780425 countsByYear W19937804252021 @default.
- W1993780425 crossrefType "journal-article" @default.
- W1993780425 hasAuthorship W1993780425A5008702027 @default.
- W1993780425 hasAuthorship W1993780425A5017004747 @default.
- W1993780425 hasAuthorship W1993780425A5022350572 @default.
- W1993780425 hasAuthorship W1993780425A5023668199 @default.
- W1993780425 hasAuthorship W1993780425A5024396594 @default.
- W1993780425 hasAuthorship W1993780425A5047523000 @default.
- W1993780425 hasAuthorship W1993780425A5072389210 @default.
- W1993780425 hasAuthorship W1993780425A5077198827 @default.
- W1993780425 hasAuthorship W1993780425A5080107089 @default.
- W1993780425 hasConcept C104317684 @default.
- W1993780425 hasConcept C129312508 @default.
- W1993780425 hasConcept C153911025 @default.
- W1993780425 hasConcept C171958077 @default.
- W1993780425 hasConcept C183978625 @default.
- W1993780425 hasConcept C2777003663 @default.
- W1993780425 hasConcept C2778923194 @default.
- W1993780425 hasConcept C54355233 @default.
- W1993780425 hasConcept C552990157 @default.
- W1993780425 hasConcept C62478195 @default.
- W1993780425 hasConcept C86339819 @default.
- W1993780425 hasConcept C86803240 @default.
- W1993780425 hasConcept C95444343 @default.
- W1993780425 hasConceptScore W1993780425C104317684 @default.
- W1993780425 hasConceptScore W1993780425C129312508 @default.
- W1993780425 hasConceptScore W1993780425C153911025 @default.
- W1993780425 hasConceptScore W1993780425C171958077 @default.
- W1993780425 hasConceptScore W1993780425C183978625 @default.
- W1993780425 hasConceptScore W1993780425C2777003663 @default.
- W1993780425 hasConceptScore W1993780425C2778923194 @default.
- W1993780425 hasConceptScore W1993780425C54355233 @default.
- W1993780425 hasConceptScore W1993780425C552990157 @default.
- W1993780425 hasConceptScore W1993780425C62478195 @default.
- W1993780425 hasConceptScore W1993780425C86339819 @default.
- W1993780425 hasConceptScore W1993780425C86803240 @default.
- W1993780425 hasConceptScore W1993780425C95444343 @default.
- W1993780425 hasFunder F4320321001 @default.
- W1993780425 hasIssue "16" @default.
- W1993780425 hasLocation W19937804251 @default.
- W1993780425 hasLocation W19937804252 @default.
- W1993780425 hasOpenAccess W1993780425 @default.
- W1993780425 hasPrimaryLocation W19937804251 @default.
- W1993780425 hasRelatedWork W1627826996 @default.
- W1993780425 hasRelatedWork W1947442001 @default.
- W1993780425 hasRelatedWork W1993780425 @default.
- W1993780425 hasRelatedWork W2049105407 @default.
- W1993780425 hasRelatedWork W2091159641 @default.
- W1993780425 hasRelatedWork W2103700294 @default.
- W1993780425 hasRelatedWork W2361577624 @default.
- W1993780425 hasRelatedWork W2365509284 @default.
- W1993780425 hasRelatedWork W3141025123 @default.
- W1993780425 hasRelatedWork W4232123522 @default.
- W1993780425 hasVolume "13" @default.
- W1993780425 isParatext "false" @default.
- W1993780425 isRetracted "false" @default.
- W1993780425 magId "1993780425" @default.
- W1993780425 workType "article" @default.