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• W1993782251 abstract "The development of an artificial pancreas for the treatment of type 1 diabetes is a highly desired endeavour for type 1 diabetic patients, physicians, scientists and engineers. The development of the first miniaturized external pumps in the 70s and the pharmacokinetic properties of short acting insulin analogues, closer to physiology, have raised hopes for the elaboration of such a device. Recent technological progress in the development of continuous glucose sensors, have improved the reliability and accuracy of these devices. This has led to the development of prototypes of closed-loop system based on the combination of a continuous monitor, a control algorithm, and an insulin pump. This review focuses on the SC-SC approach, employing subcutaneous glucose monitoring and subcutaneous insulin delivery. The feasibility of this solution has been proven at a small scale, but remains to be confirmed in the home setting. Intermediate solutions, such as semiautomatic systems, might be immediately valuable. Le développement d’un pancréas artificiel est un objectif hautement désirable pour les patients diabétiques de type 1, les médecins, les scientifiques et les ingénieurs. La mise au point des premières pompes externes miniaturisées dans les années 70, et les propriétés pharmacocinétiques des analogues de l’insuline de durée d’action brève, plus proche de la physiologie, ont suscité des espoirs pour l’élaboration d’un tel outil. Les progrès technologiques récents dans le développement des capteurs de glucose ont amélioré leur sûreté et leur précision. Ceci a permis l’élaboration de prototypes de systèmes en boucle fermée fondés sur la combinaison d’un moniteur continu de glucose, d’un algorithme de contrôle et d’une pompe à insuline. Cette revue est centrée sur l’approche SC-SC, qui utilise la mesure souscutanée du glucose et l’administration sous-cutanée de l’insuline. La faisabilité de cette démarche a été prouvée à petite échelle, mais reste à démontrer en ambulatoire. Des solutions intermédiaires, telles que les systèmes semi-automatiques, pourraient présenter un intérêt immédiat." @default.
• W1993782251 created "2016-06-24" @default.
• W1993782251 creator A5041840200 @default.
• W1993782251 date "2006-12-01" @default.
• W1993782251 modified "2023-09-23" @default.
• W1993782251 title "Continuous glucose monitoring and external insulin pump: towards a subcutaneous closed loop" @default.
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• W1993782251 doi "https://doi.org/10.1016/s1262-3636(06)72808-7" @default.
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