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• W1993784231 abstract "Involvement of the second breast is a challenging issue in breast cancer. There are still controversies on the incidence, distinction between secondary and new primary carcinoma and on the prognosis of these patients. Among the 3165 patients with breast cancer treated between 1974–1984 in the Institute of Oncology Bucharest, 106 had bilateral breast cancer (3.34%) either simultaneously (synchronous) 31 cases (0.97%) or successively (metachronous) 75 cases (2.37%). The highest frequency of bilateral breast cancer was at patients aged between 41 and 50 years old. Metachronous bilateral cancer In over 50% of cases the cancer of the opposite breast developed after 1–4 years. Localization of the minor in the same quadrant for both breasts was not higher than 24%. The second cancer was detected at a relatively early stage compared to the first tumor. Survival rate at 10 years was much lower for these patients compared with unilateral breast cancer (17.3% versus 62%). Synchronous bilateral cancer Both breasts were involved simultaneously or in less than 1 year one after the other. The high rate of stage III breast cancer (49%) and the much lower survival rate (9.7%) plead for an aggressive evolution of these cases. In Conclusion bilateral cancer is associated with poor prognosis and a multimodal treatment is mandatory. Involvement of the second breast is a challenging issue in breast cancer. There are still controversies on the incidence, distinction between secondary and new primary carcinoma and on the prognosis of these patients. Among the 3165 patients with breast cancer treated between 1974–1984 in the Institute of Oncology Bucharest, 106 had bilateral breast cancer (3.34%) either simultaneously (synchronous) 31 cases (0.97%) or successively (metachronous) 75 cases (2.37%). The highest frequency of bilateral breast cancer was at patients aged between 41 and 50 years old. In over 50% of cases the cancer of the opposite breast developed after 1–4 years. Localization of the minor in the same quadrant for both breasts was not higher than 24%. The second cancer was detected at a relatively early stage compared to the first tumor. Survival rate at 10 years was much lower for these patients compared with unilateral breast cancer (17.3% versus 62%). Both breasts were involved simultaneously or in less than 1 year one after the other. The high rate of stage III breast cancer (49%) and the much lower survival rate (9.7%) plead for an aggressive evolution of these cases. bilateral cancer is associated with poor prognosis and a multimodal treatment is mandatory." @default.
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• W1993784231 date "1995-11-01" @default.
• W1993784231 modified "2023-09-26" @default.
• W1993784231 title "1044 Bilateral carcinoma of the breast" @default.
• W1993784231 doi "https://doi.org/10.1016/0959-8049(95)96292-l" @default.
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