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• W1993788400 abstract "Recent studies have shown that mitochondria play a role in the regulation of myogenesis. Indeed, the abundance, morphology, and functional properties of mitochondria become altered when the myoblasts differentiate into myotubes. For example, mitochondrial mass/volume, mtDNA copy number, and mitochondrial respiration are markedly increased after the onset of myogenic differentiation. Besides, mitochondrial enzyme activity is also increased, suggesting that the metabolic shift from glycolysis to oxidative phosphorylation as the major energy source occurs during myogenic differentiation. Several lines of evidence suggest that impairment of mitochondrial function and activity blocks myogenic differentiation. However, yet little is known about the molecular mechanisms underlying the regulation of myogenesis by mitochondria. Understanding how mitochondria are involved in myogenesis will provide a valuable insight into the underlying mechanisms that regulate the maintenance of cellular homeostasis. Here, we will summarize the current knowledge regarding the role of mitochondria as a potential regulator of myogenesis." @default.
• W1993788400 created "2016-06-24" @default.
• W1993788400 creator A5008276546 @default.
• W1993788400 creator A5009921954 @default.
• W1993788400 date "2013-01-01" @default.
• W1993788400 modified "2023-10-03" @default.
• W1993788400 title "Mitochondria as a Potential Regulator of Myogenesis" @default.
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• W1993788400 doi "https://doi.org/10.1155/2013/593267" @default.
• W1993788400 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3574753" @default.
• W1993788400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23431256" @default.
• W1993788400 hasPublicationYear "2013" @default.
• W1993788400 type Work @default.

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