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- W1993793701 abstract "The autoimmune diseases in humans are a common and signifi cant cause of morbidity in populations. Although knowledge of the genetic basis of disease and the molecular mechanisms underpinning the infl ammatory cascades in autoimmunity are increasing, the factors that determine the spatiotemporal aspects of disease expression are poorly understood. Here I address these dynamical issues by suggesting that the unit of disease propagation is the genetic regulatory network. I fi rst consider the genetic regulatory network’s dynamical behaviour in terms of autoantigen expression, and then develop a statistical model comparing the information-theoretic quantities mutual information and Shannon entropy in healthy and diseased tissue. The results are discussed in the context of disease onset and propagation and from the perspective of evolutionary stability." @default.
- W1993793701 created "2016-06-24" @default.
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- W1993793701 date "2004-01-01" @default.
- W1993793701 modified "2023-10-18" @default.
- W1993793701 title "Genetic Network Dynamics, Information Processing and Autoimmune Disease" @default.
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- W1993793701 doi "https://doi.org/10.1159/000087850" @default.
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