FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993804396> ?p ?o ?g. }

• W1993804396 endingPage "267" @default.
• W1993804396 startingPage "267" @default.
• W1993804396 abstract "Almotriptan malate (ALM), indicated for the treatment of migraine in adults is not a drug candidate feasible to be administered through the oral route during the attack due to its associated symptoms such as nausea and vomiting. This obviates an alternative dosage form and nasal drug delivery is a good substitute to oral and parenteral administration.Gellan gum (GG) microspheres of ALM, for intranasal administration were prepared by water-in-oil emulsification cross-linking technique employing a 2(3) factorial design. Drug to polymer ratio, calcium chloride concentration and cross-linking time were selected as independent variables, while particle size and in vitro mucoadhesion of the microspheres were investigated as dependent variables. Regression analysis was performed to identify the best formulation conditions. The microspheres were evaluated for characteristics such as practical percentage yield, particle size, percentage incorporation efficiency, swellability, zeta potential, in vitro mucoadhesion, thermal analysis, X-ray diffraction study, and in vitro drug diffusion studies.The shape and surface characteristics of the microspheres were determined by scanning electron microscopy, which revealed spherical nature and nearly smooth surface with drug incorporation efficiency in the range of 71.65 ± 1.09% - 91.65 ± 1.13%. In vitro mucoadhesion was observed the range of 79.45 ± 1.69% - 95.48 ± 1.27%. Differential scanning calorimetry and X-ray diffraction results indicated a molecular level dispersion of drug in the microspheres. In vitro drug diffusion was Higuchi matrix controlled and the release mechanism was found to be non-Fickian. Stability studies indicated that there were no significant deviations in the drug content, in vitro mucoadhesion and in vitro drug diffusion characteristics.The investigation revealed promising potential of GG microspheres for delivering ALM intranasally for the treatment of migraine." @default.
• W1993804396 created "2016-06-24" @default.
• W1993804396 creator A5002940466 @default.
• W1993804396 creator A5063207663 @default.
• W1993804396 date "2014-01-01" @default.
• W1993804396 modified "2023-10-09" @default.
• W1993804396 title "Gellan gum-based mucoadhesive microspheres of almotriptan for nasal administration: Formulation optimization using factorial design, characterization, and in vitro evaluation" @default.
• W1993804396 cites W105399413 @default.
• W1993804396 cites W1788547428 @default.
• W1993804396 cites W1986367116 @default.
• W1993804396 cites W1987052484 @default.
• W1993804396 cites W1987617726 @default.
• W1993804396 cites W1991092566 @default.
• W1993804396 cites W2005680863 @default.
• W1993804396 cites W2009202656 @default.
• W1993804396 cites W2011778887 @default.
• W1993804396 cites W2023696243 @default.
• W1993804396 cites W2028303750 @default.
• W1993804396 cites W2038780553 @default.
• W1993804396 cites W2042896447 @default.
• W1993804396 cites W2046190665 @default.
• W1993804396 cites W2049626483 @default.
• W1993804396 cites W2057225377 @default.
• W1993804396 cites W2057233173 @default.
• W1993804396 cites W2066486583 @default.
• W1993804396 cites W207190506 @default.
• W1993804396 cites W2078545247 @default.
• W1993804396 cites W2080499918 @default.
• W1993804396 cites W2085940166 @default.
• W1993804396 cites W2087611912 @default.
• W1993804396 cites W2089895093 @default.
• W1993804396 cites W2094560758 @default.
• W1993804396 cites W2115439624 @default.
• W1993804396 cites W2125009604 @default.
• W1993804396 cites W2130781340 @default.
• W1993804396 cites W2133001175 @default.
• W1993804396 cites W2153127321 @default.
• W1993804396 cites W2158034889 @default.
• W1993804396 cites W2171132700 @default.
• W1993804396 cites W2407037522 @default.
• W1993804396 doi "https://doi.org/10.4103/0975-7406.142959" @default.
• W1993804396 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4231387" @default.
• W1993804396 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25400410" @default.
• W1993804396 hasPublicationYear "2014" @default.
• W1993804396 type Work @default.
• W1993804396 sameAs 1993804396 @default.
• W1993804396 citedByCount "30" @default.
• W1993804396 countsByYear W19938043962015 @default.
• W1993804396 countsByYear W19938043962016 @default.
• W1993804396 countsByYear W19938043962018 @default.
• W1993804396 countsByYear W19938043962019 @default.
• W1993804396 countsByYear W19938043962020 @default.
• W1993804396 countsByYear W19938043962021 @default.
• W1993804396 countsByYear W19938043962022 @default.
• W1993804396 countsByYear W19938043962023 @default.
• W1993804396 crossrefType "journal-article" @default.
• W1993804396 hasAuthorship W1993804396A5002940466 @default.
• W1993804396 hasAuthorship W1993804396A5063207663 @default.
• W1993804396 hasBestOaLocation W19938043961 @default.
• W1993804396 hasConcept C105795698 @default.
• W1993804396 hasConcept C121332964 @default.
• W1993804396 hasConcept C13245373 @default.
• W1993804396 hasConcept C136229726 @default.
• W1993804396 hasConcept C147789679 @default.
• W1993804396 hasConcept C155672457 @default.
• W1993804396 hasConcept C169222746 @default.
• W1993804396 hasConcept C171250308 @default.
• W1993804396 hasConcept C185592680 @default.
• W1993804396 hasConcept C187530423 @default.
• W1993804396 hasConcept C192562407 @default.
• W1993804396 hasConcept C2779820397 @default.
• W1993804396 hasConcept C2780020223 @default.
• W1993804396 hasConcept C2781220964 @default.
• W1993804396 hasConcept C31903555 @default.
• W1993804396 hasConcept C33923547 @default.
• W1993804396 hasConcept C39519442 @default.
• W1993804396 hasConcept C43617362 @default.
• W1993804396 hasConcept C71924100 @default.
• W1993804396 hasConcept C85663871 @default.
• W1993804396 hasConcept C86181022 @default.
• W1993804396 hasConcept C97355855 @default.
• W1993804396 hasConcept C98274493 @default.
• W1993804396 hasConceptScore W1993804396C105795698 @default.
• W1993804396 hasConceptScore W1993804396C121332964 @default.
• W1993804396 hasConceptScore W1993804396C13245373 @default.
• W1993804396 hasConceptScore W1993804396C136229726 @default.
• W1993804396 hasConceptScore W1993804396C147789679 @default.
• W1993804396 hasConceptScore W1993804396C155672457 @default.
• W1993804396 hasConceptScore W1993804396C169222746 @default.
• W1993804396 hasConceptScore W1993804396C171250308 @default.
• W1993804396 hasConceptScore W1993804396C185592680 @default.
• W1993804396 hasConceptScore W1993804396C187530423 @default.
• W1993804396 hasConceptScore W1993804396C192562407 @default.
• W1993804396 hasConceptScore W1993804396C2779820397 @default.
• W1993804396 hasConceptScore W1993804396C2780020223 @default.
• W1993804396 hasConceptScore W1993804396C2781220964 @default.
• W1993804396 hasConceptScore W1993804396C31903555 @default.
• W1993804396 hasConceptScore W1993804396C33923547 @default.

• next