FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993811543> ?p ?o ?g. }

• W1993811543 endingPage "1282" @default.
• W1993811543 startingPage "1275" @default.
• W1993811543 abstract "Background: Dendritic cells (DC) can exert powerful immune stimulatory as well as regulatory functions and are therefore important tools for therapeutic strategies. Dexamethasone (Dex) was previously shown to inhibit DC maturation and to induce regulatory properties both in vitro and in vivo. Here, we investigated the immunoregulatory role of DexDC in two different rat acute rejection models of kidney transplantation. Methods: Rat DC were generated from BN and DA bone marrow in the presence of the corticosteroid, Dex. The function of Dex-modulated DC was analyzed in vitro and in vivo, using a BN to LEW and a DA to LEW renal transplantation model in the absence of other forms of immunosuppression. T cells of transplanted rats were isolated and restimulated with donor mature DC (lipopolysaccharide [LPS] or CD40L activated). T-cell responsiveness was analyzed by proliferative capacity and IFN-γ production. Results: Stimulation of Dex-modulated rat DC with LPS resulted in normal IL-10 production, whereas synthesis of IL-12 was impaired. In accordance, the capacity of LPS-DexDC to stimulate T-cell activation was decreased. In both renal transplantation models, treatment with donor-derived LPS-DexDC induced a significant donor-specific T-cell hyporesponse. However, pretreatment did not result in a prolonged graft survival. Conclusions: In two fully mismatched kidney transplantation models, donor-derived LPS-DexDC induce a donor-specific T-cell hyporesponse. However, in this setting allograft survival was not improved, suggesting an important role for T cells with indirect alloreactivity. Understanding the underlying mechanism involved in the rejection process will improve the development of a cell-based immunotherapy." @default.
• W1993811543 created "2016-06-24" @default.
• W1993811543 creator A5012066076 @default.
• W1993811543 creator A5028411602 @default.
• W1993811543 creator A5061625184 @default.
• W1993811543 creator A5069641539 @default.
• W1993811543 creator A5072401995 @default.
• W1993811543 creator A5077849585 @default.
• W1993811543 creator A5083194978 @default.
• W1993811543 date "2008-11-15" @default.
• W1993811543 modified "2023-10-02" @default.
• W1993811543 title "Induction of Donor-Specific T-Cell Hyporesponsiveness Using Dexamethasone-Treated Dendritic Cells in Two Fully Mismatched Rat Kidney Transplantation Models" @default.
• W1993811543 cites W1530235393 @default.
• W1993811543 cites W1661544713 @default.
• W1993811543 cites W1713856372 @default.
• W1993811543 cites W1955379330 @default.
• W1993811543 cites W1960538598 @default.
• W1993811543 cites W1972758309 @default.
• W1993811543 cites W1996709249 @default.
• W1993811543 cites W2007751085 @default.
• W1993811543 cites W2014452295 @default.
• W1993811543 cites W2024104871 @default.
• W1993811543 cites W2027249090 @default.
• W1993811543 cites W2028116439 @default.
• W1993811543 cites W2031817202 @default.
• W1993811543 cites W2040413744 @default.
• W1993811543 cites W2051907403 @default.
• W1993811543 cites W2057793002 @default.
• W1993811543 cites W2061393519 @default.
• W1993811543 cites W2084006363 @default.
• W1993811543 cites W2085756406 @default.
• W1993811543 cites W2089327657 @default.
• W1993811543 cites W2091863545 @default.
• W1993811543 cites W2101336470 @default.
• W1993811543 cites W2101781154 @default.
• W1993811543 cites W2131635315 @default.
• W1993811543 cites W2134934993 @default.
• W1993811543 cites W2148434143 @default.
• W1993811543 cites W2161354474 @default.
• W1993811543 cites W2171722021 @default.
• W1993811543 cites W325332095 @default.
• W1993811543 doi "https://doi.org/10.1097/tp.0b013e31818a6682" @default.
• W1993811543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19005410" @default.
• W1993811543 hasPublicationYear "2008" @default.
• W1993811543 type Work @default.
• W1993811543 sameAs 1993811543 @default.
• W1993811543 citedByCount "21" @default.
• W1993811543 countsByYear W19938115432012 @default.
• W1993811543 countsByYear W19938115432013 @default.
• W1993811543 countsByYear W19938115432014 @default.
• W1993811543 countsByYear W19938115432016 @default.
• W1993811543 countsByYear W19938115432021 @default.
• W1993811543 countsByYear W19938115432022 @default.
• W1993811543 countsByYear W19938115432023 @default.
• W1993811543 crossrefType "journal-article" @default.
• W1993811543 hasAuthorship W1993811543A5012066076 @default.
• W1993811543 hasAuthorship W1993811543A5028411602 @default.
• W1993811543 hasAuthorship W1993811543A5061625184 @default.
• W1993811543 hasAuthorship W1993811543A5069641539 @default.
• W1993811543 hasAuthorship W1993811543A5072401995 @default.
• W1993811543 hasAuthorship W1993811543A5077849585 @default.
• W1993811543 hasAuthorship W1993811543A5083194978 @default.
• W1993811543 hasBestOaLocation W19938115431 @default.
• W1993811543 hasConcept C126322002 @default.
• W1993811543 hasConcept C150903083 @default.
• W1993811543 hasConcept C203014093 @default.
• W1993811543 hasConcept C207001950 @default.
• W1993811543 hasConcept C2776090121 @default.
• W1993811543 hasConcept C2778170410 @default.
• W1993811543 hasConcept C2778740727 @default.
• W1993811543 hasConcept C2778754761 @default.
• W1993811543 hasConcept C2780091579 @default.
• W1993811543 hasConcept C2780252810 @default.
• W1993811543 hasConcept C2780401358 @default.
• W1993811543 hasConcept C2911091166 @default.
• W1993811543 hasConcept C71924100 @default.
• W1993811543 hasConcept C86803240 @default.
• W1993811543 hasConcept C8891405 @default.
• W1993811543 hasConceptScore W1993811543C126322002 @default.
• W1993811543 hasConceptScore W1993811543C150903083 @default.
• W1993811543 hasConceptScore W1993811543C203014093 @default.
• W1993811543 hasConceptScore W1993811543C207001950 @default.
• W1993811543 hasConceptScore W1993811543C2776090121 @default.
• W1993811543 hasConceptScore W1993811543C2778170410 @default.
• W1993811543 hasConceptScore W1993811543C2778740727 @default.
• W1993811543 hasConceptScore W1993811543C2778754761 @default.
• W1993811543 hasConceptScore W1993811543C2780091579 @default.
• W1993811543 hasConceptScore W1993811543C2780252810 @default.
• W1993811543 hasConceptScore W1993811543C2780401358 @default.
• W1993811543 hasConceptScore W1993811543C2911091166 @default.
• W1993811543 hasConceptScore W1993811543C71924100 @default.
• W1993811543 hasConceptScore W1993811543C86803240 @default.
• W1993811543 hasConceptScore W1993811543C8891405 @default.
• W1993811543 hasIssue "9" @default.
• W1993811543 hasLocation W19938115431 @default.
• W1993811543 hasLocation W19938115432 @default.
• W1993811543 hasLocation W19938115433 @default.
• W1993811543 hasOpenAccess W1993811543 @default.

• next