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• W1993813448 endingPage "1539" @default.
• W1993813448 startingPage "1535" @default.
• W1993813448 abstract "The mutagenic activity of the major DNA adduct formed by the liver carcinogen aflatoxin B1 (AFB1) was investigated in vivo. An oligonucleotide containing a single 8,9-dihydro-8-(N7-guanyl)-9-hydroxyaflatoxin B1 (AFB1-N7-Gua) adduct was inserted into the single-stranded genome of bacteriophage M13. Replication in SOS-induced Escherichia coli yielded a mutation frequency for AFB1-N7-Gua of 4%. The predominant mutation was G --> T, identical to the principal mutation in human liver tumors believed to be induced by aflatoxin. The G --> T mutations of AFB1-N7-Gua, unlike those (if the AFB1-N7-Gua-derived apurinic site, were much more strongly dependent on MucAB than UmuDC, a pattern matching that in intact cells treated with the toxin. It is concluded that the AFB1-N7-Gua adduct, and not the apurinic site, has genetic requirements for mutagenesis that best explain mutations in aflatoxin-treated cells. While most mutations were targeted to the site of the lesion, a significant fraction (13%) occurred at the base 5' to the modified guanine. In contrast, the apurinic site-containing genome gave rise only to targeted mutations. The mutational asymmetry observed for AFB1-N7-Gua is consistent with structural models indicating that the aflatoxin moiety of the aflatoxin guanine adduct is covalently intercalated on the 5' face of the guanine residue. These results suggest a molecular mechanism that could explain an important step in the carcinogenicity of aflatoxin B1." @default.
• W1993813448 created "2016-06-24" @default.
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• W1993813448 date "1996-02-20" @default.
• W1993813448 modified "2023-10-01" @default.
• W1993813448 title "Mutational properties of the primary aflatoxin B1-DNA adduct." @default.
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• W1993813448 doi "https://doi.org/10.1073/pnas.93.4.1535" @default.
• W1993813448 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/39975" @default.
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