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- W1993813711 abstract "The cis-2a,3-diol and the trans-4,5-, trans-7,8-, trans-9,10- and trans-11,12-dihydrodiols of 3-methylcholanthrene and the trans-3,4, trans-5,6-, trans-8,9- and trans-10,11- dihydrodiols of 7,12-dimethylbenz[a]-anthrancene have been tested, in comparison with the parent hydrocarbons, for their abilities to initiate skin tumours in female CDI mice. Groups of mice received a single topical application (25 μg) of a diol or of a hydrocarbon, and 1 week later repeated topical applications (1 μg) of 12–0-tetradecanoyl-phorbol-13-acetate were commenced. The results show that the diols capable of being converted into bay-region vicinal diol-epoxides, i.e. the 9,10-diol of 3-methylcholanthrene and the 3,4-diol of 7,12-dimethylbenz[a]anthrancene were active as initiating agents but that they were no more active than their parent hydrocarbon. The K-region 5,6-diol of 7,12-dimethylbenz[a]anthrancene, which cannot be converted directly into a vicinal diol-epoxide, was also active as a tumour-initiating agent when applied to mouse skin." @default.
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- W1993813711 date "1979-10-15" @default.
- W1993813711 modified "2023-09-24" @default.
- W1993813711 title "The initiation of tumours on mouse skin by dihydrodiols derived from 7,12-dimethylbenz(a)anthracene and 3-methylcholanthrene" @default.
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- W1993813711 doi "https://doi.org/10.1002/ijc.2910240413" @default.
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