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- W1993814892 abstract "Abstract 1. 1. When Fe2+ was added to a microsome suspension prepared from rat liver, there was an uptake of O2 and a concomitant lipid peroxidation. These reactions were uninfluenced by the addition of ADP or NADPH2. 2. 2. The addition of Fe3+ to a liver-microsomal suspension increased O2 uptake and lipid peroxidation in the presence of ADP and NADPH2. 3. 3. Ethylenediaminetetraacetate and antimycin A inhibited O2 uptake by rat- liver microsomes in the presence of NADPH2 and ADP, and this inhibition was reversed by the addition of Fe3+. 4. 4. The supernatant obtained after separating the microsomes by centrifugation at 105000 × g, inhibited O2 uptake by the microsomes in the presence of NADPH2 and low concentrations of ADP (2 μmoles/ml), and this inhibition was reversed by the addition of ADP (a further 2 μmoles/ml). 5. 5. Cytochrome b5 was reduced by addition of NADPH2 in the presence of antimycin A which blocked O2 uptake. The cytochrome was re-oxidized on addition of Fe3+ and ADP together. 6. 6. A tentative scheme for the participation of iron in the oxidation of NADPH2 in rat-liver microsomes is discussed." @default.
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- W1993814892 date "1965-03-01" @default.
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- W1993814892 title "Influence of iron on oxidation of reduced nicotinamide- adenine-dinucleotide phosphate in rat-liver microsomes" @default.
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- W1993814892 doi "https://doi.org/10.1016/0304-4165(65)90152-2" @default.
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