FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993816098> ?p ?o ?g. }

• W1993816098 endingPage "3257" @default.
• W1993816098 startingPage "3257" @default.
• W1993816098 abstract "Oligonucleotides can be covalently linked to peptides composed of any sequence of amino acids by solid phase fragment condensation. The peptides incorporated into the conjugates include nuclear localizing signals (NLS), nuclear export signals (NES), membrane fusion domain of some viral proteins and some designed peptides with amphipathic character. Evaluation of biological properties of DNA–peptide conjugates indicated that (a) the conjugates could bind to target RNA and dsDNA with increased affinity, (b) the conjugates were more resistant to cellular nuclease degradation, (c) the conjugate–RNA hybrids could activate RNase H as effectively as native oligonucleotides, (d) the conjugates with fusion peptides showed largely enhanced cellular uptake, (e) the conjugates with NLS could be predominantly delivered into the cell nucleus, (f) the conjugates with NES could be localized in the cytoplasm. As a result, antisense oligonucleotides conjugated with NLS could inhibit human telomerase in human leukemia cells much more strongly than phosphorothioate oligonucleotides." @default.
• W1993816098 created "2016-06-24" @default.
• W1993816098 creator A5000366018 @default.
• W1993816098 creator A5012744077 @default.
• W1993816098 creator A5063543498 @default.
• W1993816098 creator A5064366813 @default.
• W1993816098 creator A5073720264 @default.
• W1993816098 creator A5078458496 @default.
• W1993816098 date "2005-01-01" @default.
• W1993816098 modified "2023-09-23" @default.
• W1993816098 title "Controlled intracellular localization and enhanced antisense effect of oligonucleotides by chemical conjugation" @default.
• W1993816098 cites W1968866064 @default.
• W1993816098 cites W1977643768 @default.
• W1993816098 cites W1986882083 @default.
• W1993816098 cites W1997660008 @default.
• W1993816098 cites W1998745896 @default.
• W1993816098 cites W2016455999 @default.
• W1993816098 cites W2024735180 @default.
• W1993816098 cites W2036326817 @default.
• W1993816098 cites W2036425276 @default.
• W1993816098 cites W2044286897 @default.
• W1993816098 cites W2049944281 @default.
• W1993816098 cites W2052973382 @default.
• W1993816098 cites W2053327612 @default.
• W1993816098 cites W2057658284 @default.
• W1993816098 cites W2058975342 @default.
• W1993816098 cites W2060606238 @default.
• W1993816098 cites W2089408908 @default.
• W1993816098 cites W2091716703 @default.
• W1993816098 cites W2110419228 @default.
• W1993816098 cites W2122675272 @default.
• W1993816098 cites W2123377969 @default.
• W1993816098 cites W2138668121 @default.
• W1993816098 cites W2173844423 @default.
• W1993816098 cites W2249249956 @default.
• W1993816098 doi "https://doi.org/10.1039/b507691a" @default.
• W1993816098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16132084" @default.
• W1993816098 hasPublicationYear "2005" @default.
• W1993816098 type Work @default.
• W1993816098 sameAs 1993816098 @default.
• W1993816098 citedByCount "26" @default.
• W1993816098 countsByYear W19938160982012 @default.
• W1993816098 countsByYear W19938160982014 @default.
• W1993816098 countsByYear W19938160982015 @default.
• W1993816098 countsByYear W19938160982016 @default.
• W1993816098 countsByYear W19938160982017 @default.
• W1993816098 countsByYear W19938160982020 @default.
• W1993816098 countsByYear W19938160982021 @default.
• W1993816098 countsByYear W19938160982022 @default.
• W1993816098 countsByYear W19938160982023 @default.
• W1993816098 crossrefType "journal-article" @default.
• W1993816098 hasAuthorship W1993816098A5000366018 @default.
• W1993816098 hasAuthorship W1993816098A5012744077 @default.
• W1993816098 hasAuthorship W1993816098A5063543498 @default.
• W1993816098 hasAuthorship W1993816098A5064366813 @default.
• W1993816098 hasAuthorship W1993816098A5073720264 @default.
• W1993816098 hasAuthorship W1993816098A5078458496 @default.
• W1993816098 hasConcept C104317684 @default.
• W1993816098 hasConcept C10879258 @default.
• W1993816098 hasConcept C129312508 @default.
• W1993816098 hasConcept C134306372 @default.
• W1993816098 hasConcept C153911025 @default.
• W1993816098 hasConcept C185592680 @default.
• W1993816098 hasConcept C186435350 @default.
• W1993816098 hasConcept C190062978 @default.
• W1993816098 hasConcept C197336794 @default.
• W1993816098 hasConcept C2777271071 @default.
• W1993816098 hasConcept C2779281246 @default.
• W1993816098 hasConcept C33923547 @default.
• W1993816098 hasConcept C49805395 @default.
• W1993816098 hasConcept C552990157 @default.
• W1993816098 hasConcept C55493867 @default.
• W1993816098 hasConcept C67705224 @default.
• W1993816098 hasConcept C86803240 @default.
• W1993816098 hasConceptScore W1993816098C104317684 @default.
• W1993816098 hasConceptScore W1993816098C10879258 @default.
• W1993816098 hasConceptScore W1993816098C129312508 @default.
• W1993816098 hasConceptScore W1993816098C134306372 @default.
• W1993816098 hasConceptScore W1993816098C153911025 @default.
• W1993816098 hasConceptScore W1993816098C185592680 @default.
• W1993816098 hasConceptScore W1993816098C186435350 @default.
• W1993816098 hasConceptScore W1993816098C190062978 @default.
• W1993816098 hasConceptScore W1993816098C197336794 @default.
• W1993816098 hasConceptScore W1993816098C2777271071 @default.
• W1993816098 hasConceptScore W1993816098C2779281246 @default.
• W1993816098 hasConceptScore W1993816098C33923547 @default.
• W1993816098 hasConceptScore W1993816098C49805395 @default.
• W1993816098 hasConceptScore W1993816098C552990157 @default.
• W1993816098 hasConceptScore W1993816098C55493867 @default.
• W1993816098 hasConceptScore W1993816098C67705224 @default.
• W1993816098 hasConceptScore W1993816098C86803240 @default.
• W1993816098 hasIssue "18" @default.
• W1993816098 hasLocation W19938160981 @default.
• W1993816098 hasLocation W19938160982 @default.
• W1993816098 hasOpenAccess W1993816098 @default.
• W1993816098 hasPrimaryLocation W19938160981 @default.
• W1993816098 hasRelatedWork W1982010715 @default.
• W1993816098 hasRelatedWork W1982308640 @default.

• next