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• W1993820274 abstract "Abstract During axonal regeneration synthesis of different growth‐associated proteins is increased. As yet there is no clear picture of the specific contribution made by the transcriptional and post‐transcriptional machinery that provides the gene products necessary for process outgrowth. Here we focus our study on the transcriptional processes in neurons by using intron‐directed in situ hybridization to the primary transcript of a brain growth protein GAP‐43. In most brain regions, levels of primary transcript expression of GAP‐43 were highly correlated with levels of its mRNA. However, there were notable dissociations: in hippocampal granule cells, high levels of primary transcript were evident yet no GAP‐43 mRNA was detected. In locus coeruleus the reverse was true; there were high levels of GAP‐43 mRNA but no detectable primary transcript. A primary transcript antitermination mechanism is proposed to explain the first dissociation, and a post‐transcriptional mRNA stabilization mechanism to explain the second. Transcriptional activation during nerve regeneration was monitored by assessing primary transcript induction of GAP‐43 in mouse facial motor neurons. This induction, as well as its mRNA, was restricted to the side of the facial nerve crush. Increases were first observed at 24 h with a rapid increase in both measures up to 3 days. To our knowledge, this is the first in vivo evidence demonstrating transcriptional activation of a brain growth protein in regenerating neurons. The present study points to the GAP‐43 transcriptional mechanism as a key determinant of GAP‐43 synthesis. Along with the recruitment of post‐transcriptional mechanisms, such synthesis occurs in response to both intrinsic developmental programs and extrinsic environmental signals." @default.
• W1993820274 created "2016-06-24" @default.
• W1993820274 creator A5014319407 @default.
• W1993820274 creator A5054396192 @default.
• W1993820274 date "2000-09-01" @default.
• W1993820274 modified "2023-10-18" @default.
• W1993820274 title "Transcriptional and post-transcriptional regulation of a brain growth protein: regional differentiation and regeneration induction of GAP-43" @default.
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• W1993820274 doi "https://doi.org/10.1046/j.1460-9568.2000.00196.x" @default.
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