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- W1993820504 abstract "Variant Creutzfeldt-Jakob disease and bovine spongiform encephalopathy are initiated by extracerebral exposure to prions. Although prion transmission from extracerebral sites to the brain represents a potential target for prophylaxis, attempts at vaccination have been limited by the poor immunogenicity of prion proteins. To circumvent this, we expressed an anti-prion protein (anti-PrP) μ chain in Prnp o/o mice. Transgenic mice developed sustained anti-PrP titers, which were not suppressed by introduction of Prnp + alleles. Transgene expression prevented pathogenesis of prions introduced by intraperitoneal injection in the spleen and brain. Expression of endogenous PrP (PrP C ) in the spleen and brain was unaffected, suggesting that immunity was responsible for protection. This indicates the feasibility of immunological inhibition of prion disease in vivo." @default.
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- W1993820504 date "2001-10-05" @default.
- W1993820504 modified "2023-10-14" @default.
- W1993820504 title "Prevention of Scrapie Pathogenesis by Transgenic Expression of Anti-Prion Protein Antibodies" @default.
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- W1993820504 doi "https://doi.org/10.1126/science.1063093" @default.
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