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- W1993822243 abstract "Synergistic or additive effects of combined treatments with carcinogens or promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)-initiated rat bladder carcinogenesis were examined. Male F344 rats were given BBN as an initiator followed by low doses of 3 sodium salts (sodium bicarbonate, sodium L-ascorbate and sodium citrate) and/or 3 antioxidants (butylated hydroxyanisole, butylated hydroxytoluene and tertiary butylhydroxyquinone). Combined treatments with 3 sodium salts or 3 antioxidants, and especially all 6 chemicals together promoted bladder carcinogenesis. In addition, these combined treatments were associated with increased DNA synthesis of the bladder epithelium. Combined administration of the carcinogens, o-anisidine, p-cresidine, and 4-chloro-o-phenylenedi-amine at low doses also enhanced BBN-initiated bladder carcinogenesis. These results indicate that environmental carcinogens or promoters can exert synergistic or additive actions on bladder cancer induction." @default.
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- W1993822243 date "1992-09-01" @default.
- W1993822243 modified "2023-09-30" @default.
- W1993822243 title "Synergism of Environmental Carcinogens and Promoters on Bladder Cancer Development Initiated by N-Butyl-N-(4-hydroxybutyl)nitrosamine in F344 Rats" @default.
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- W1993822243 doi "https://doi.org/10.1111/j.1349-7006.1992.tb02007.x" @default.
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