FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993832021> ?p ?o ?g. }

• W1993832021 endingPage "1309" @default.
• W1993832021 startingPage "1303" @default.
• W1993832021 abstract "Much research is now being conducted in order to understand the role of cytokines in the development of the inflammatory response following trauma. The purpose of this study was to evaluate whether serum levels of certain cytokines, measured immediately after initial injury, can be used as potential biomarkers for predicting the development and the degree of severity of the systemic inflammatory response (SIRS) in patients with moderate and severe trauma.We conducted a prospective study with 71 individuals of whom 13 (18.3 %) were healthy controls and 58 (81.7 %) were traumatized orthopaedic patients who were categorized into two groups: 31 (43.6 %) with moderate injuries and 27 (38.1 %) patients with severe orthopaedic trauma. Thirty cc of heparinized blood were drawn from each individual within a few hours after the injury. Serum levels of pro-inflammatory, regulatory and anti-inflammatory cytokines were measured in each individual participant.High levels of pro-inflammatory cytokines IL-1β,-6,-8,-12, tumour necrosis factor alpha and interferon gamma were found in all injured patients compared to healthy controls. Only IL-6 and IL-8 were significantly higher in the injured patients. Levels of the regulatory cytokines, transformed growth factor beta (TGF-β) and IL-10 were higher in the injured patients, but significant only for TGF-β. Levels of IL-4 were significantly lower in the injured groups as compared to the controls.Secretion of large amounts of pro-inflammatory cytokines and decreased level of anti-inflammatory cytokines during the acute phase of trauma may lead to the development of systemic inflammatory response syndrome (SIRS) in unstable polytraumatized patients. SIRS may result in life threatening conditions as acute respiratory distress syndrome (ARDS) and multiple organ failure (MOF). High levels of IL-6, IL-8, TGFβ and low levels of IL-4 were found to be reliable markers for the existence of immune reactivity in trauma patients. More research is needed to study pattern of cytokine levels along the acute period of injury, after surgical interventions and during recovery." @default.
• W1993832021 created "2016-06-24" @default.
• W1993832021 creator A5001129370 @default.
• W1993832021 creator A5010054033 @default.
• W1993832021 creator A5033874660 @default.
• W1993832021 creator A5070034615 @default.
• W1993832021 creator A5072036488 @default.
• W1993832021 creator A5091165259 @default.
• W1993832021 date "2014-01-09" @default.
• W1993832021 modified "2023-10-02" @default.
• W1993832021 title "Cytokine Levels (IL-4, IL-6, IL-8 and TGFβ) as Potential Biomarkers of Systemic Inflammatory Response in Trauma Patients" @default.
• W1993832021 cites W1972229497 @default.
• W1993832021 cites W1992420142 @default.
• W1993832021 cites W2025756876 @default.
• W1993832021 cites W2028565783 @default.
• W1993832021 cites W2042575430 @default.
• W1993832021 cites W2052564398 @default.
• W1993832021 cites W2054745662 @default.
• W1993832021 cites W2055206094 @default.
• W1993832021 cites W2057481037 @default.
• W1993832021 cites W2089650230 @default.
• W1993832021 cites W2094209140 @default.
• W1993832021 cites W2097492875 @default.
• W1993832021 cites W2099091315 @default.
• W1993832021 cites W2116333903 @default.
• W1993832021 cites W2139669335 @default.
• W1993832021 cites W2159184393 @default.
• W1993832021 cites W2164244927 @default.
• W1993832021 cites W2171342470 @default.
• W1993832021 cites W2247141267 @default.
• W1993832021 cites W2316067769 @default.
• W1993832021 cites W2329826771 @default.
• W1993832021 cites W2334132217 @default.
• W1993832021 cites W2790054139 @default.
• W1993832021 cites W2983909743 @default.
• W1993832021 cites W3023923910 @default.
• W1993832021 cites W4205456610 @default.
• W1993832021 cites W4293108385 @default.
• W1993832021 doi "https://doi.org/10.1007/s00264-013-2261-2" @default.
• W1993832021 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4037528" @default.
• W1993832021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24402554" @default.
• W1993832021 hasPublicationYear "2014" @default.
• W1993832021 type Work @default.
• W1993832021 sameAs 1993832021 @default.
• W1993832021 citedByCount "98" @default.
• W1993832021 countsByYear W19938320212014 @default.
• W1993832021 countsByYear W19938320212015 @default.
• W1993832021 countsByYear W19938320212016 @default.
• W1993832021 countsByYear W19938320212017 @default.
• W1993832021 countsByYear W19938320212018 @default.
• W1993832021 countsByYear W19938320212019 @default.
• W1993832021 countsByYear W19938320212020 @default.
• W1993832021 countsByYear W19938320212021 @default.
• W1993832021 countsByYear W19938320212022 @default.
• W1993832021 countsByYear W19938320212023 @default.
• W1993832021 crossrefType "journal-article" @default.
• W1993832021 hasAuthorship W1993832021A5001129370 @default.
• W1993832021 hasAuthorship W1993832021A5010054033 @default.
• W1993832021 hasAuthorship W1993832021A5033874660 @default.
• W1993832021 hasAuthorship W1993832021A5070034615 @default.
• W1993832021 hasAuthorship W1993832021A5072036488 @default.
• W1993832021 hasAuthorship W1993832021A5091165259 @default.
• W1993832021 hasBestOaLocation W19938320212 @default.
• W1993832021 hasConcept C126322002 @default.
• W1993832021 hasConcept C141071460 @default.
• W1993832021 hasConcept C164027704 @default.
• W1993832021 hasConcept C17991360 @default.
• W1993832021 hasConcept C188816634 @default.
• W1993832021 hasConcept C203014093 @default.
• W1993832021 hasConcept C2776914184 @default.
• W1993832021 hasConcept C2778384902 @default.
• W1993832021 hasConcept C2778690821 @default.
• W1993832021 hasConcept C2781090800 @default.
• W1993832021 hasConcept C3020196126 @default.
• W1993832021 hasConcept C68312169 @default.
• W1993832021 hasConcept C71924100 @default.
• W1993832021 hasConcept C74172505 @default.
• W1993832021 hasConcept C90924648 @default.
• W1993832021 hasConceptScore W1993832021C126322002 @default.
• W1993832021 hasConceptScore W1993832021C141071460 @default.
• W1993832021 hasConceptScore W1993832021C164027704 @default.
• W1993832021 hasConceptScore W1993832021C17991360 @default.
• W1993832021 hasConceptScore W1993832021C188816634 @default.
• W1993832021 hasConceptScore W1993832021C203014093 @default.
• W1993832021 hasConceptScore W1993832021C2776914184 @default.
• W1993832021 hasConceptScore W1993832021C2778384902 @default.
• W1993832021 hasConceptScore W1993832021C2778690821 @default.
• W1993832021 hasConceptScore W1993832021C2781090800 @default.
• W1993832021 hasConceptScore W1993832021C3020196126 @default.
• W1993832021 hasConceptScore W1993832021C68312169 @default.
• W1993832021 hasConceptScore W1993832021C71924100 @default.
• W1993832021 hasConceptScore W1993832021C74172505 @default.
• W1993832021 hasConceptScore W1993832021C90924648 @default.
• W1993832021 hasIssue "6" @default.
• W1993832021 hasLocation W19938320211 @default.
• W1993832021 hasLocation W19938320212 @default.
• W1993832021 hasLocation W19938320213 @default.
• W1993832021 hasLocation W19938320214 @default.

• next