Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993834170> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1993834170 endingPage "118" @default.
- W1993834170 startingPage "114" @default.
- W1993834170 abstract "Pancreatic exocrine function and bile secretion were examined in cholecystokinin (CCK)-B receptor gene-targeted mice and compared among different genotypes [i.e., CCK-B receptor gene: (+/+), wild-type; (+/-), heterozygous; and (-/-), homozygous deficient]. The histology and protein concentrations in the pancreas also were examined. Amylase release from the dispersed acini was examined in vitro by using the various doses of CCK-8, carbachol, and secretin. In vivo, the bile and pancreatic juice were collected, and the concentrations of amylase and bile acid were measured in anesthetized mice. The responses to CCK (100 pmol/kg) or acetyl-beta-methylcholine (500 nmol/kg) were examined. In vitro studies showed that the maximal effective concentrations of CCK-8 (10(-l0) M), carbachol (10(-5) M), and secretin (5 x 10(-7) M) were comparable for all genotypes. Fluid, amylase, and bile acid outputs in vivo also were comparable for all genotypes. Pancreatic wet weight and protein concentrations were not significantly different, and no abnormal findings were observed on histologic examination in any genotype. These results indicated that the CCK-B receptor has no role in pancreatic growth, exocrine secretion, or bile secretion in adult mice." @default.
- W1993834170 created "2016-06-24" @default.
- W1993834170 creator A5005171926 @default.
- W1993834170 creator A5015417105 @default.
- W1993834170 creator A5026226470 @default.
- W1993834170 creator A5027762345 @default.
- W1993834170 creator A5034072814 @default.
- W1993834170 creator A5038907642 @default.
- W1993834170 creator A5040083710 @default.
- W1993834170 creator A5046954073 @default.
- W1993834170 creator A5055281656 @default.
- W1993834170 creator A5057261637 @default.
- W1993834170 creator A5076985077 @default.
- W1993834170 creator A5090298115 @default.
- W1993834170 date "1999-08-01" @default.
- W1993834170 modified "2023-09-27" @default.
- W1993834170 title "Disruption of Cholecystokinin (CCK)-B Receptor Gene Did Not Modify Bile or Pancreatic Secretion or Pancreatic Growth" @default.
- W1993834170 doi "https://doi.org/10.1097/00006676-199908000-00002" @default.
- W1993834170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10438156" @default.
- W1993834170 hasPublicationYear "1999" @default.
- W1993834170 type Work @default.
- W1993834170 sameAs 1993834170 @default.
- W1993834170 citedByCount "22" @default.
- W1993834170 countsByYear W19938341702013 @default.
- W1993834170 countsByYear W19938341702015 @default.
- W1993834170 crossrefType "journal-article" @default.
- W1993834170 hasAuthorship W1993834170A5005171926 @default.
- W1993834170 hasAuthorship W1993834170A5015417105 @default.
- W1993834170 hasAuthorship W1993834170A5026226470 @default.
- W1993834170 hasAuthorship W1993834170A5027762345 @default.
- W1993834170 hasAuthorship W1993834170A5034072814 @default.
- W1993834170 hasAuthorship W1993834170A5038907642 @default.
- W1993834170 hasAuthorship W1993834170A5040083710 @default.
- W1993834170 hasAuthorship W1993834170A5046954073 @default.
- W1993834170 hasAuthorship W1993834170A5055281656 @default.
- W1993834170 hasAuthorship W1993834170A5057261637 @default.
- W1993834170 hasAuthorship W1993834170A5076985077 @default.
- W1993834170 hasAuthorship W1993834170A5090298115 @default.
- W1993834170 hasConcept C118303440 @default.
- W1993834170 hasConcept C126322002 @default.
- W1993834170 hasConcept C134018914 @default.
- W1993834170 hasConcept C150903083 @default.
- W1993834170 hasConcept C170493617 @default.
- W1993834170 hasConcept C170835558 @default.
- W1993834170 hasConcept C181199279 @default.
- W1993834170 hasConcept C185592680 @default.
- W1993834170 hasConcept C207001950 @default.
- W1993834170 hasConcept C2777593968 @default.
- W1993834170 hasConcept C2777951760 @default.
- W1993834170 hasConcept C2778677841 @default.
- W1993834170 hasConcept C2778764654 @default.
- W1993834170 hasConcept C2778988552 @default.
- W1993834170 hasConcept C32110497 @default.
- W1993834170 hasConcept C55493867 @default.
- W1993834170 hasConcept C57380142 @default.
- W1993834170 hasConcept C71924100 @default.
- W1993834170 hasConcept C86803240 @default.
- W1993834170 hasConceptScore W1993834170C118303440 @default.
- W1993834170 hasConceptScore W1993834170C126322002 @default.
- W1993834170 hasConceptScore W1993834170C134018914 @default.
- W1993834170 hasConceptScore W1993834170C150903083 @default.
- W1993834170 hasConceptScore W1993834170C170493617 @default.
- W1993834170 hasConceptScore W1993834170C170835558 @default.
- W1993834170 hasConceptScore W1993834170C181199279 @default.
- W1993834170 hasConceptScore W1993834170C185592680 @default.
- W1993834170 hasConceptScore W1993834170C207001950 @default.
- W1993834170 hasConceptScore W1993834170C2777593968 @default.
- W1993834170 hasConceptScore W1993834170C2777951760 @default.
- W1993834170 hasConceptScore W1993834170C2778677841 @default.
- W1993834170 hasConceptScore W1993834170C2778764654 @default.
- W1993834170 hasConceptScore W1993834170C2778988552 @default.
- W1993834170 hasConceptScore W1993834170C32110497 @default.
- W1993834170 hasConceptScore W1993834170C55493867 @default.
- W1993834170 hasConceptScore W1993834170C57380142 @default.
- W1993834170 hasConceptScore W1993834170C71924100 @default.
- W1993834170 hasConceptScore W1993834170C86803240 @default.
- W1993834170 hasIssue "2" @default.
- W1993834170 hasLocation W19938341701 @default.
- W1993834170 hasLocation W19938341702 @default.
- W1993834170 hasOpenAccess W1993834170 @default.
- W1993834170 hasPrimaryLocation W19938341701 @default.
- W1993834170 hasRelatedWork W1977702912 @default.
- W1993834170 hasRelatedWork W1993834170 @default.
- W1993834170 hasRelatedWork W2039848084 @default.
- W1993834170 hasRelatedWork W2057070381 @default.
- W1993834170 hasRelatedWork W2068757463 @default.
- W1993834170 hasRelatedWork W2089405254 @default.
- W1993834170 hasRelatedWork W2417891006 @default.
- W1993834170 hasRelatedWork W2473535734 @default.
- W1993834170 hasRelatedWork W309416608 @default.
- W1993834170 hasRelatedWork W2043830906 @default.
- W1993834170 hasVolume "19" @default.
- W1993834170 isParatext "false" @default.
- W1993834170 isRetracted "false" @default.
- W1993834170 magId "1993834170" @default.
- W1993834170 workType "article" @default.