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• W1993837490 abstract "The Rho family of guanine triphosphate hydrolases controls various cellular processes, including cell migration. We describe here the demonstration of a role for a RhoA GTPase homologue during cell migration in Caenorhabditis elegans. We show that eliminating or reducing rho-1 gene function by using a dominant-negative transgene or dsRNA interference results in a severe defect in migration of hypodermal P cells to a ventral position. Biochemical and genetic data also suggest that unc-73 , which encodes a Trio-like guanine nucleotide exchange factor, may act as an activator of rho-1 in the migration process. Mutations in let-502 ROCK, a homologue of a RhoA effector in mammals, also cause defects in P cell migration, suggesting that it may be one of several effectors acting downstream of rho-1 during P cell migration. Finally, we provide evidence to support the idea that other small Rac subfamily small GTPases act redundantly and in parallel to RHO-1 in this specific cell migration event." @default.
• W1993837490 created "2016-06-24" @default.
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• W1993837490 date "2001-10-30" @default.
• W1993837490 modified "2023-10-16" @default.
• W1993837490 title "A RHO GTPase-mediated pathway is required during P cell migration in <i>Caenorhabditis elegans</i>" @default.
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• W1993837490 doi "https://doi.org/10.1073/pnas.241504098" @default.
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