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- W1993840368 abstract "Over the past three years 25 302 adults in Kentucky have been tested for hæmoglobinopathies, and of these, hæmoglobin A2 was measured on 3734, 1973 with microcytosis and 1761 within the normal range. The best methods of detecting β-thalassæmia minor using red-blood-cell indices were compared. No method detected all heterozygotes. A new method was devised consisting of three parts: (1) hæmoglobin electrophoresis, (2) calculation of the product of the square of the mean corpuscular volume (M.C.V.) multiplied by the mean corpuscular hæmoglobin (M.C.H.) measured in units of one hundred, (3) A2 determination on all AA samples with (M.C.V.)2 × M.C.H. <1530 and on those with variant genotypes consistent with thalassæmia. In this series this new method detected 137 out of 138 heterozygotes with 4·4% false-positives." @default.
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- W1993840368 date "1977-03-01" @default.
- W1993840368 modified "2023-09-30" @default.
- W1993840368 title "A STRATEGY TO DETECT β-THALASSÆMIA MINOR" @default.
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- W1993840368 doi "https://doi.org/10.1016/s0140-6736(77)92128-6" @default.
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