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- W1993843664 abstract "Method We analyzed methyl-cytosine profiles as evident from Methylated DNA immunoprecipitation across 39 tissues and cell lines that were available as part of the NIH RoadMap Epigenomics project. The mitochondrial reference genome used in the current study was derived from the UCSC human genome build hg19. We used custom scripts to retrieve reads mapping to the mitochondrial genome. Results Our analysis suggests that the general profile of methylated cytosines across the samples show a distinct pattern. This pattern was generally conserved across the datasets considered, with exceptions of a few regions which showed variability in methylation amongst datasets analyzed. We show that certain regions of the mitochondria could be differentially methylated in datasets which show distinct temporal and functional characteristics, like Brain and Blood. One such region harbors the loci associated with mitochondrial encoded NADH dehydrogenase (MTND6), variations in which are associated with neurological disorders. To date this is the first and comprehensive analyses of genome-scale methylation data for Human mitochondria." @default.
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- W1993843664 date "2014-01-01" @default.
- W1993843664 modified "2023-10-16" @default.
- W1993843664 title "Comparative analysis of human mitochondrial methylome show distinct patterns of epigenetic regulation in mitochondria" @default.
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- W1993843664 doi "https://doi.org/10.1186/1755-8166-7-s1-p86" @default.
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