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- W1993843713 abstract "We have measured plasma extravasation in response to stimulation of the rat hind footpad with wool fabric. The stimulus was delivered using a constantly weighted disc of wool rotating at 4 revolutions per minute for 30 min on the base of blisters induced by vacuum. The protein content of prestimulated blister base perfusate was 38±2 μg/ml in a 30-min collection. With stimulation this increased to 80±10 μg/ml (P < 0.001; Student's paired t-test). No increase in plasma extravasation was observed in adult animals pretreated as neonates with capsaicin indicating that the plasma extravasation observed was neurogenically mediated. Plasma extravasation was also observed with substance P added to the perfusate. The threshold for substance P-induced plasma extravasation was 2 × 10−11 mol/30 min. These results suggest that neurogenic inflammation induced by the mechanical stimulus of wool fabric may be mediated by substance P. This reaction may be involved in wool-induced prickle and itch noted in some individuals." @default.
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- W1993843713 date "1986-05-01" @default.
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- W1993843713 title "Neurogenic inflammation caused by wool fabric in the rat; Possible mediation by substance P" @default.
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- W1993843713 doi "https://doi.org/10.1016/0304-3940(86)90041-8" @default.
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