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- W1993846314 endingPage "42" @default.
- W1993846314 startingPage "33" @default.
- W1993846314 abstract "The interleukin (IL)-17 cytokine family members IL-17A and IL-17F mediate inflammatory activities via the IL-17 receptor (IL-17R) complex, comprised of the IL-17RA and IL-17RC subunits. Proper regulation of the IL-17 signaling axis results in effective host defense against extracellular pathogens, while aberrant signaling can drive autoimmune pathology. Elucidating the molecular mechanisms underlying IL-17 signal transduction can yield an enhanced understanding of inflammatory immune processes and also create an avenue for therapeutic intervention in the treatment of IL-17-dependent diseases. To date, the fundamental signaling mechanisms used by the IL-17R complex are still incompletely defined. While current structure–function studies have primarily focused on the IL-17RA subunit, recent research indicates that the IL-17RC subunit plays a key role in modulating IL-17 responses. This review will examine what is known regarding IL-17RC function and provide a framework for future work on this subunit and its impact on human health." @default.
- W1993846314 created "2016-06-24" @default.
- W1993846314 creator A5015257895 @default.
- W1993846314 creator A5049895849 @default.
- W1993846314 date "2009-12-13" @default.
- W1993846314 modified "2023-10-01" @default.
- W1993846314 title "IL-17RC: a partner in IL-17 signaling and beyond" @default.
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