FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993847461> ?p ?o ?g. }

• W1993847461 endingPage "319" @default.
• W1993847461 startingPage "311" @default.
• W1993847461 abstract "Although histopathologic criteria for adrenal cortical nodular hyperplasias (ACNHs) and adenomas (ACAs) have been developed, their kinetics and clonality are virtually unknown. We studied 20 ACNHs and 25 ACAs (based on World Health Organization criteria) from 45 females. Representative samples were histologically evaluated, and the methylation pattern of the androgen receptor alleles was analyzed on microdissected samples. Consecutive sections were selected for slide cytometry, flow cytometry, and in situ end labeling (ISEL). Apoptosis was studied by flow cytometry (nuclear area/DNA content plotter analysis) and by ISEL. Appropriate tissue controls were run in every case. Polyclonal gel patterns were revealed in 14/18 informative ACNHs and in 3/22 informative ACAs, whereas monoclonal gel patterns were observed in 4/18 ACNHs and 19/22 ACAs. Overlapping proliferation rates (PRs) were observed in both clonal groups, and apoptosis was detected only in G(0)/G(1) cells, especially in monoclonal ACNHs (3/4; 75%) and in polyclonal ACAs (2/3; 67%). Significantly higher PRs were observed in ACNHs with polyclonal patterns and G(0)/G(1) apoptosis and in ACAs regardless of clonality pattern and presence of G(0)/G(1) apoptosis. All except one ACNH (19/20; 95%) and 15/25 ACAs (60%) showed diploid DNA content, whereas the remaining cases were hyperdiploid. A direct correlation between PR and ISEL was observed in polyclonal lesions (PR = 29.32 ISEL - 1.93), whereas the correlation was inverse for monoclonal lesions (PR = -9.13 ISEL + 21.57). We concluded that only simultaneous down-regulated apoptosis and high proliferation result in selective kinetic advantage, dominant clone expansion, and unbalanced methylation patterns of androgen receptor alleles in ACNHs and ACAs." @default.
• W1993847461 created "2016-06-24" @default.
• W1993847461 creator A5002835039 @default.
• W1993847461 creator A5053964269 @default.
• W1993847461 creator A5055075606 @default.
• W1993847461 creator A5072872701 @default.
• W1993847461 creator A5073113433 @default.
• W1993847461 creator A5085385071 @default.
• W1993847461 date "2000-01-01" @default.
• W1993847461 modified "2023-10-18" @default.
• W1993847461 title "Clonality as Expression of Distinctive Cell Kinetics Patterns in Nodular Hyperplasias and Adenomas of the Adrenal Cortex" @default.
• W1993847461 cites W113984154 @default.
• W1993847461 cites W1518721136 @default.
• W1993847461 cites W15821043 @default.
• W1993847461 cites W1585869774 @default.
• W1993847461 cites W1590590817 @default.
• W1993847461 cites W1592941919 @default.
• W1993847461 cites W161538641 @default.
• W1993847461 cites W1672621735 @default.
• W1993847461 cites W1694120588 @default.
• W1993847461 cites W1738248009 @default.
• W1993847461 cites W1885316483 @default.
• W1993847461 cites W1912261041 @default.
• W1993847461 cites W1967304777 @default.
• W1993847461 cites W1987308186 @default.
• W1993847461 cites W1989901426 @default.
• W1993847461 cites W1993762151 @default.
• W1993847461 cites W1997791231 @default.
• W1993847461 cites W2001589308 @default.
• W1993847461 cites W2008868417 @default.
• W1993847461 cites W2008930108 @default.
• W1993847461 cites W2014733420 @default.
• W1993847461 cites W2015358596 @default.
• W1993847461 cites W2018708063 @default.
• W1993847461 cites W2039764143 @default.
• W1993847461 cites W2043087065 @default.
• W1993847461 cites W2046750945 @default.
• W1993847461 cites W2052853635 @default.
• W1993847461 cites W2053954735 @default.
• W1993847461 cites W2059834237 @default.
• W1993847461 cites W2060359113 @default.
• W1993847461 cites W2124307602 @default.
• W1993847461 cites W2139620481 @default.
• W1993847461 cites W2144285397 @default.
• W1993847461 cites W2144663706 @default.
• W1993847461 cites W2148219033 @default.
• W1993847461 cites W2168744717 @default.
• W1993847461 cites W2171051267 @default.
• W1993847461 cites W2178018641 @default.
• W1993847461 cites W2297784182 @default.
• W1993847461 cites W2335629628 @default.
• W1993847461 cites W2404855454 @default.
• W1993847461 cites W2410059302 @default.
• W1993847461 cites W2412692800 @default.
• W1993847461 cites W2507320858 @default.
• W1993847461 cites W290487434 @default.
• W1993847461 cites W69814473 @default.
• W1993847461 doi "https://doi.org/10.1016/s0002-9440(10)64732-3" @default.
• W1993847461 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1868630" @default.
• W1993847461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10623680" @default.
• W1993847461 hasPublicationYear "2000" @default.
• W1993847461 type Work @default.
• W1993847461 sameAs 1993847461 @default.
• W1993847461 citedByCount "50" @default.
• W1993847461 countsByYear W19938474612012 @default.
• W1993847461 countsByYear W19938474612013 @default.
• W1993847461 countsByYear W19938474612014 @default.
• W1993847461 countsByYear W19938474612015 @default.
• W1993847461 countsByYear W19938474612016 @default.
• W1993847461 countsByYear W19938474612017 @default.
• W1993847461 countsByYear W19938474612018 @default.
• W1993847461 countsByYear W19938474612019 @default.
• W1993847461 crossrefType "journal-article" @default.
• W1993847461 hasAuthorship W1993847461A5002835039 @default.
• W1993847461 hasAuthorship W1993847461A5053964269 @default.
• W1993847461 hasAuthorship W1993847461A5055075606 @default.
• W1993847461 hasAuthorship W1993847461A5072872701 @default.
• W1993847461 hasAuthorship W1993847461A5073113433 @default.
• W1993847461 hasAuthorship W1993847461A5085385071 @default.
• W1993847461 hasBestOaLocation W19938474612 @default.
• W1993847461 hasConcept C142724271 @default.
• W1993847461 hasConcept C153911025 @default.
• W1993847461 hasConcept C159654299 @default.
• W1993847461 hasConcept C163864487 @default.
• W1993847461 hasConcept C190283241 @default.
• W1993847461 hasConcept C203014093 @default.
• W1993847461 hasConcept C204232928 @default.
• W1993847461 hasConcept C542903549 @default.
• W1993847461 hasConcept C54355233 @default.
• W1993847461 hasConcept C553184892 @default.
• W1993847461 hasConcept C71924100 @default.
• W1993847461 hasConcept C86803240 @default.
• W1993847461 hasConcept C956191 @default.
• W1993847461 hasConceptScore W1993847461C142724271 @default.
• W1993847461 hasConceptScore W1993847461C153911025 @default.
• W1993847461 hasConceptScore W1993847461C159654299 @default.
• W1993847461 hasConceptScore W1993847461C163864487 @default.
• W1993847461 hasConceptScore W1993847461C190283241 @default.

• next