Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993857781> ?p ?o ?g. }
- W1993857781 endingPage "218" @default.
- W1993857781 startingPage "210" @default.
- W1993857781 abstract "Curcumin, one of the most studied chemopreventive agents, is a natural compound extracted from Curcuma longa L. Extensive research over the last half century has revealed that curcumin can inhibit the proliferation of various tumor cells in culture, prevent carcinogen induced cancers in rodents and inhibit the growth of human tumors in xenotransplant or orthotransplant animal models. Several phase I and phase II clinical trials indicated that curcumin is quite safe and may exhibit therapeutic efficacy. The utility of curcumin is limited by its lack of water solubility and relatively low in vivo bioavailability. Multiple approaches including nanoparticles, liposomes, micelles and phospholipid complexes are being sought to overcome these limitations. This review describes the general properties of curcumin and its potential effect against cancer including evidences of its antitumor action in vitro, in vivo, clinically and the strategies to overcome its low bioavailability. Keywords: Curcumin, Chemoprevention, Anti-cancer, Formulation, hexahydrocurcumin, gastrointestinal cancers, tyrosine-phosphorylation, carcinogenic, bioavailability, egg-phosphatidylcholine" @default.
- W1993857781 created "2016-06-24" @default.
- W1993857781 creator A5016017821 @default.
- W1993857781 creator A5028541832 @default.
- W1993857781 creator A5042864647 @default.
- W1993857781 date "2012-03-01" @default.
- W1993857781 modified "2023-10-06" @default.
- W1993857781 title "Curcumin and its Formulations: Potential Anti-Cancer Agents" @default.
- W1993857781 cites W1975055683 @default.
- W1993857781 cites W1975770667 @default.
- W1993857781 cites W1976194786 @default.
- W1993857781 cites W1980828424 @default.
- W1993857781 cites W1982397837 @default.
- W1993857781 cites W1982728351 @default.
- W1993857781 cites W1983082314 @default.
- W1993857781 cites W1997149430 @default.
- W1993857781 cites W1999312756 @default.
- W1993857781 cites W2009412611 @default.
- W1993857781 cites W2014060948 @default.
- W1993857781 cites W2019536742 @default.
- W1993857781 cites W2021330396 @default.
- W1993857781 cites W2023695651 @default.
- W1993857781 cites W2033431239 @default.
- W1993857781 cites W2035308484 @default.
- W1993857781 cites W2036647198 @default.
- W1993857781 cites W2042237966 @default.
- W1993857781 cites W2046574646 @default.
- W1993857781 cites W2048388386 @default.
- W1993857781 cites W2056778760 @default.
- W1993857781 cites W2060857477 @default.
- W1993857781 cites W2061981941 @default.
- W1993857781 cites W2067540563 @default.
- W1993857781 cites W2071356759 @default.
- W1993857781 cites W2078071390 @default.
- W1993857781 cites W2079250655 @default.
- W1993857781 cites W2083769086 @default.
- W1993857781 cites W2084583180 @default.
- W1993857781 cites W2089531507 @default.
- W1993857781 cites W2093939556 @default.
- W1993857781 cites W2099023764 @default.
- W1993857781 cites W2100543468 @default.
- W1993857781 cites W2101761370 @default.
- W1993857781 cites W2104526249 @default.
- W1993857781 cites W2110167136 @default.
- W1993857781 cites W2110311974 @default.
- W1993857781 cites W2110431757 @default.
- W1993857781 cites W2111019406 @default.
- W1993857781 cites W2111361573 @default.
- W1993857781 cites W2112459736 @default.
- W1993857781 cites W2113518731 @default.
- W1993857781 cites W2114300637 @default.
- W1993857781 cites W2114373278 @default.
- W1993857781 cites W2115400066 @default.
- W1993857781 cites W2115613269 @default.
- W1993857781 cites W2115869230 @default.
- W1993857781 cites W2118728914 @default.
- W1993857781 cites W2120002897 @default.
- W1993857781 cites W2123375980 @default.
- W1993857781 cites W2124881032 @default.
- W1993857781 cites W2128541396 @default.
- W1993857781 cites W2129397604 @default.
- W1993857781 cites W2131357228 @default.
- W1993857781 cites W2135770108 @default.
- W1993857781 cites W2137407924 @default.
- W1993857781 cites W2137631271 @default.
- W1993857781 cites W2139443876 @default.
- W1993857781 cites W2141909270 @default.
- W1993857781 cites W2145887093 @default.
- W1993857781 cites W2146278165 @default.
- W1993857781 cites W2148437395 @default.
- W1993857781 cites W2151015976 @default.
- W1993857781 cites W2156211060 @default.
- W1993857781 cites W2157122000 @default.
- W1993857781 cites W2158764684 @default.
- W1993857781 cites W2159626225 @default.
- W1993857781 cites W2160044295 @default.
- W1993857781 cites W2161233858 @default.
- W1993857781 cites W2162537150 @default.
- W1993857781 cites W2163762983 @default.
- W1993857781 cites W2167927545 @default.
- W1993857781 cites W2168273700 @default.
- W1993857781 cites W2168829937 @default.
- W1993857781 cites W2169136645 @default.
- W1993857781 cites W2169972304 @default.
- W1993857781 cites W2172024684 @default.
- W1993857781 cites W2185302041 @default.
- W1993857781 cites W2239089021 @default.
- W1993857781 cites W2413775972 @default.
- W1993857781 cites W2419269917 @default.
- W1993857781 cites W296450459 @default.
- W1993857781 cites W74993898 @default.
- W1993857781 doi "https://doi.org/10.2174/187152012800228733" @default.
- W1993857781 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22044005" @default.
- W1993857781 hasPublicationYear "2012" @default.
- W1993857781 type Work @default.
- W1993857781 sameAs 1993857781 @default.
- W1993857781 citedByCount "61" @default.
- W1993857781 countsByYear W19938577812012 @default.