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• W1993858563 startingPage "2477" @default.
• W1993858563 abstract "Abstract Polyhalogenated hydrocarbons have been implicated in the anomalous sexual differentiation of mammals and reptiles. Here, a temperature‐sensitive turtle sex determination assay using the red‐eared slider ( Trachemys scripta elegans ) was used to determine the estrogenic or antiestrogenic activity of 2,3,7,8‐tetrachlorodibenzo‐ p ‐dioxin (TCDD) and 3,3′,4,4′,5‐pentachlorobiphenyl (PCB‐126). Neither TCDD nor PCB‐126 showed a statistically significant difference in the resulting sex ratios (Fisher's exact test, p < 0.45). As a consequence of the dosing technique (eggshell spotting), the shell retained 90 and 96% of the dose for PCB‐126 and TCDD, respectively, similar to retention of estradiol‐17β. However, the dosing allowed transfer of sufficient chemical to achieve tissue concentrations that were greater than most concentrations reported for environmentally incurred residues. Similar relative mass distributions of PCB‐126 and TCDD were observed in albumin (14–20%), yolk (55–70%), and embryo (16–25%). Relative concentration distributions in the embryo approached those in the yolk, 37 to 40% and 40 to 52%, respectively, while relative concentrations in the albumin remained at 11 to 20%. Lipid‐normalized TCDD and PCB‐126 concentrations were 30‐ to 40‐fold greater in the embryo than in the yolk. It is hypothesized that nonpassive partitioning processes may have occurred in the embryo." @default.
• W1993858563 created "2016-06-24" @default.
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• W1993858563 date "2002-11-01" @default.
• W1993858563 modified "2023-10-16" @default.
• W1993858563 title "Turtle sex determination assay: Mass balance and responses to 2,3,7,8-tetrachlorodibenzo-<i>p</i>-dioxin and 3,3′,4,4′,5-pentachlorobiphenyl" @default.
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• W1993858563 doi "https://doi.org/10.1002/etc.5620211129" @default.
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