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- W1993864657 abstract "1. The effect of chronic administration of an tidepre ssant s and electroconvu1sive shock (ESC) on the hypothermic response (HTR) induced by 8-hydroxy-2-(di-n-propyramino)te tralin (8-OH-DPAT) as an index of the function of 5-HT1A receptors was investigated in the rat. 2. 8-OH-DPAT dose-dependently decreased the rectal temperature. 3. Pretreatment with parachlorophenylalanine increased HTR. 4. Chronic administration of the an tidepressants, trazodone, imipramine, amitriptyline, and fluoxetine had no effect on HTR, whereas administration of clorgyline attenuated HTR significantly. 5. Repeated ECS had no effect on HTR. 6. These results suggest that the action site of 8-OH-DPAT is postsynaptic 5-HT1A receptors and that the chronic administration of some an tidepressants and ECS has no direct action on these receptors. 7. Therefore, the an tidepressant effects of these drugs are not produced by direct action on postsynaptic 5-HT1A receptors." @default.
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- W1993864657 date "1994-03-01" @default.
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- W1993864657 title "The effect of chronic administration of antidepressants and electroconvulsive shock on the 5-HT1A receptor mediated hypothekmic response induced by 8-OH-DPAT in the rat" @default.
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- W1993864657 doi "https://doi.org/10.1016/0278-5846(94)90072-8" @default.
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