FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993873263> ?p ?o ?g. }

• W1993873263 endingPage "1659" @default.
• W1993873263 startingPage "1659" @default.
• W1993873263 abstract "The capability of the antibody (Ab) repertoire to mount a response to appropriate epitopes on infectious agents will strongly affect the ability of the immune system to provide protection against disease. Certain epitopes may be poor inducers of immunity but are nevertheless able to promote biologically important protection when recognized by the immune repertoire. We have investigated the recognition by Ab of one such poorly immunogenic target, antigenic domain 2 (AD-2) on human cytomegalovirus glycoprotein B. To date, only two well-characterized human monoclonal Ab reactive with this epitope are known. To define parameters important for establishment of a human paratope recognizing this epitope, we created variants of the variable genes utilized by one of these Ab and used phage display technology to select Ab fragments with retained antigen specificity. We show here that residues in the first complementarity determining region of both the heavy and the light chain are involved in determining the AD-2 specificity and, in addition, that key mutations in the germ-line sequence are required for effective interaction with this epitope. Thus, the products of the human germ-line IGHV3–30 and IGKV3–11 genes, the only V genes that have been demonstrated to participate in an AD-2 specific Ab response, do not have the intrinsic features required for high-affinity recognition of this epitope. We propose that the inability of the human germ-line gene-encoded Ab repertoire to directly recognize this and possibly other antigenic determinants results in their poor immunogenicity in vivo. This may favor responses to other epitopes, which have a high-affinity imprint in the human germ-line Ab repertoire." @default.
• W1993873263 created "2016-06-24" @default.
• W1993873263 creator A5054314129 @default.
• W1993873263 creator A5059506939 @default.
• W1993873263 creator A5091376342 @default.
• W1993873263 date "2002-06-01" @default.
• W1993873263 modified "2023-10-16" @default.
• W1993873263 title "Non-germ-line encoded residues are critical for effective antibody recognition of a poorly immunogenic neutralization epitope on glycoprotein B of human cytomegalovirus" @default.
• W1993873263 cites W103608028 @default.
• W1993873263 cites W1517724708 @default.
• W1993873263 cites W1550766309 @default.
• W1993873263 cites W1561115881 @default.
• W1993873263 cites W1572321656 @default.
• W1993873263 cites W1717024783 @default.
• W1993873263 cites W1860785890 @default.
• W1993873263 cites W1879654670 @default.
• W1993873263 cites W1968772953 @default.
• W1993873263 cites W1974303748 @default.
• W1993873263 cites W1978876837 @default.
• W1993873263 cites W1980352910 @default.
• W1993873263 cites W1981197474 @default.
• W1993873263 cites W1984317000 @default.
• W1993873263 cites W1988790628 @default.
• W1993873263 cites W2000566565 @default.
• W1993873263 cites W2012873002 @default.
• W1993873263 cites W2030419415 @default.
• W1993873263 cites W2030698938 @default.
• W1993873263 cites W2035772332 @default.
• W1993873263 cites W2045817907 @default.
• W1993873263 cites W2049022159 @default.
• W1993873263 cites W2051519190 @default.
• W1993873263 cites W2059056215 @default.
• W1993873263 cites W2070505228 @default.
• W1993873263 cites W2075426113 @default.
• W1993873263 cites W2075547045 @default.
• W1993873263 cites W2076432314 @default.
• W1993873263 cites W2091477384 @default.
• W1993873263 cites W2093205821 @default.
• W1993873263 cites W2102928442 @default.
• W1993873263 cites W2108537567 @default.
• W1993873263 cites W2110036226 @default.
• W1993873263 cites W2115132122 @default.
• W1993873263 cites W2121077961 @default.
• W1993873263 cites W2125604001 @default.
• W1993873263 cites W2138415450 @default.
• W1993873263 cites W2156017880 @default.
• W1993873263 cites W2161732543 @default.
• W1993873263 cites W2166021114 @default.
• W1993873263 cites W96789131 @default.
• W1993873263 doi "https://doi.org/10.1002/1521-4141(200206)32:6<1659::aid-immu1659>3.0.co;2-9" @default.
• W1993873263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12115649" @default.
• W1993873263 hasPublicationYear "2002" @default.
• W1993873263 type Work @default.
• W1993873263 sameAs 1993873263 @default.
• W1993873263 citedByCount "16" @default.
• W1993873263 countsByYear W19938732632012 @default.
• W1993873263 countsByYear W19938732632014 @default.
• W1993873263 countsByYear W19938732632015 @default.
• W1993873263 countsByYear W19938732632020 @default.
• W1993873263 countsByYear W19938732632023 @default.
• W1993873263 crossrefType "journal-article" @default.
• W1993873263 hasAuthorship W1993873263A5054314129 @default.
• W1993873263 hasAuthorship W1993873263A5059506939 @default.
• W1993873263 hasAuthorship W1993873263A5091376342 @default.
• W1993873263 hasBestOaLocation W19938732631 @default.
• W1993873263 hasConcept C147483822 @default.
• W1993873263 hasConcept C159047783 @default.
• W1993873263 hasConcept C159654299 @default.
• W1993873263 hasConcept C186268636 @default.
• W1993873263 hasConcept C195616568 @default.
• W1993873263 hasConcept C2780868878 @default.
• W1993873263 hasConcept C2781241564 @default.
• W1993873263 hasConcept C2910693471 @default.
• W1993873263 hasConcept C542903549 @default.
• W1993873263 hasConcept C54355233 @default.
• W1993873263 hasConcept C78598654 @default.
• W1993873263 hasConcept C85630698 @default.
• W1993873263 hasConcept C86803240 @default.
• W1993873263 hasConcept C9086966 @default.
• W1993873263 hasConceptScore W1993873263C147483822 @default.
• W1993873263 hasConceptScore W1993873263C159047783 @default.
• W1993873263 hasConceptScore W1993873263C159654299 @default.
• W1993873263 hasConceptScore W1993873263C186268636 @default.
• W1993873263 hasConceptScore W1993873263C195616568 @default.
• W1993873263 hasConceptScore W1993873263C2780868878 @default.
• W1993873263 hasConceptScore W1993873263C2781241564 @default.
• W1993873263 hasConceptScore W1993873263C2910693471 @default.
• W1993873263 hasConceptScore W1993873263C542903549 @default.
• W1993873263 hasConceptScore W1993873263C54355233 @default.
• W1993873263 hasConceptScore W1993873263C78598654 @default.
• W1993873263 hasConceptScore W1993873263C85630698 @default.
• W1993873263 hasConceptScore W1993873263C86803240 @default.
• W1993873263 hasConceptScore W1993873263C9086966 @default.
• W1993873263 hasIssue "6" @default.
• W1993873263 hasLocation W19938732631 @default.
• W1993873263 hasLocation W19938732632 @default.
• W1993873263 hasOpenAccess W1993873263 @default.
• W1993873263 hasPrimaryLocation W19938732631 @default.

• next