FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993875100> ?p ?o ?g. }

• W1993875100 endingPage "251" @default.
• W1993875100 startingPage "242" @default.
• W1993875100 abstract "Abstract The objective of this study was to compare ex vivo proton high‐resolution magic angle spinning magnetic resonance spectra of intact tissue with those spectra obtained by solution 1 H NMR of brain extracts of the same sample. Sixteen brain tissue samples from simian immunodeficiency virus‐infected rhesus macaques from both frontal cortex and putamen were evaluated by comparing brain metabolite quantities of N ‐acetylaspartate (NAA), choline‐containing compounds (Cho), myo ‐inositol (MI), creatine (Cr), lactate (Lac), glutamate (Glu) and acetate (Ace). The ratios of the individual NMR peak areas of all metabolites relative to the creatine peak area were calculated. Linear regression analysis revealed significant correlations between measurements using the two methods. The strength of the correlations varied depending on the metabolite studied. We found highly significant correlations for NAA/Cr ( r 2 = 0.77; p < 0.0001), NAA + Ace/Cr ( r 2 = 0.73; p < 0.0001) and MI/Cr ( r 2 = 0.75; p < 0.0001). We observed somewhat less strong correlations for Glu/Cr ( r 2 = 0.54; p < 0.002) and Lac/Cr ( r 2 = 0.54; p < 0.002). There was a substantially weaker correlation for Cho/Cr ( r 2 = 0.32; p = 0.02). When plotting the metabolite ratios obtained by 1 H HRMAS NMR of the intact tissue sample on the ordinate vs 1 H NMR of the tissue extract on the abscissa, most metabolites exhibited a slope close to unity, and a positive intercept probably due to macromolecular contributions to the MAS spectra. The slope for Cho/Cr was substantially less than unity. Generally, samples from the frontal cortex showed a better correlation between intact and extracted tissue samples than putamen. This is most prominent in the cases of NAA/Cr and Cho/Cr. We conclude that both methods provide substantially the same information for most major brain metabolites, with the exception of the Cho resonance. Copyright © 2005 John Wiley & Sons, Ltd." @default.
• W1993875100 created "2016-06-24" @default.
• W1993875100 creator A5014130192 @default.
• W1993875100 creator A5014560567 @default.
• W1993875100 creator A5018610179 @default.
• W1993875100 creator A5024217801 @default.
• W1993875100 creator A5037519946 @default.
• W1993875100 creator A5046818334 @default.
• W1993875100 creator A5047091139 @default.
• W1993875100 creator A5066966267 @default.
• W1993875100 creator A5072007021 @default.
• W1993875100 date "2005-03-09" @default.
• W1993875100 modified "2023-10-16" @default.
• W1993875100 title "Comparisons of brain metabolites observed by HRMAS1H NMR of intact tissue and solution1H NMR of tissue extracts in SIV-infected macaques" @default.
• W1993875100 cites W1493470785 @default.
• W1993875100 cites W1571663515 @default.
• W1993875100 cites W1575873348 @default.
• W1993875100 cites W1876230661 @default.
• W1993875100 cites W1961111145 @default.
• W1993875100 cites W1988936320 @default.
• W1993875100 cites W1994358185 @default.
• W1993875100 cites W1999478240 @default.
• W1993875100 cites W2002802452 @default.
• W1993875100 cites W2005176833 @default.
• W1993875100 cites W2015214539 @default.
• W1993875100 cites W2023798788 @default.
• W1993875100 cites W2026688443 @default.
• W1993875100 cites W2027550861 @default.
• W1993875100 cites W2032382354 @default.
• W1993875100 cites W2047384740 @default.
• W1993875100 cites W2049791475 @default.
• W1993875100 cites W2051607590 @default.
• W1993875100 cites W2052040303 @default.
• W1993875100 cites W2063476577 @default.
• W1993875100 cites W2067076695 @default.
• W1993875100 cites W2070101406 @default.
• W1993875100 cites W2074925149 @default.
• W1993875100 cites W2088375959 @default.
• W1993875100 cites W2121817566 @default.
• W1993875100 cites W2138096904 @default.
• W1993875100 cites W2139194252 @default.
• W1993875100 cites W2142105308 @default.
• W1993875100 cites W2145022634 @default.
• W1993875100 cites W2146515399 @default.
• W1993875100 cites W2147351662 @default.
• W1993875100 cites W2152546327 @default.
• W1993875100 cites W2157725061 @default.
• W1993875100 cites W2315888296 @default.
• W1993875100 cites W53210441 @default.
• W1993875100 doi "https://doi.org/10.1002/nbm.953" @default.
• W1993875100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15759297" @default.
• W1993875100 hasPublicationYear "2005" @default.
• W1993875100 type Work @default.
• W1993875100 sameAs 1993875100 @default.
• W1993875100 citedByCount "37" @default.
• W1993875100 countsByYear W19938751002012 @default.
• W1993875100 countsByYear W19938751002013 @default.
• W1993875100 countsByYear W19938751002014 @default.
• W1993875100 countsByYear W19938751002015 @default.
• W1993875100 countsByYear W19938751002017 @default.
• W1993875100 countsByYear W19938751002018 @default.
• W1993875100 countsByYear W19938751002019 @default.
• W1993875100 countsByYear W19938751002021 @default.
• W1993875100 countsByYear W19938751002022 @default.
• W1993875100 countsByYear W19938751002023 @default.
• W1993875100 crossrefType "journal-article" @default.
• W1993875100 hasAuthorship W1993875100A5014130192 @default.
• W1993875100 hasAuthorship W1993875100A5014560567 @default.
• W1993875100 hasAuthorship W1993875100A5018610179 @default.
• W1993875100 hasAuthorship W1993875100A5024217801 @default.
• W1993875100 hasAuthorship W1993875100A5037519946 @default.
• W1993875100 hasAuthorship W1993875100A5046818334 @default.
• W1993875100 hasAuthorship W1993875100A5047091139 @default.
• W1993875100 hasAuthorship W1993875100A5066966267 @default.
• W1993875100 hasAuthorship W1993875100A5072007021 @default.
• W1993875100 hasConcept C121332964 @default.
• W1993875100 hasConcept C1276947 @default.
• W1993875100 hasConcept C185592680 @default.
• W1993875100 hasConcept C2777477808 @default.
• W1993875100 hasConcept C2779896295 @default.
• W1993875100 hasConcept C2781123555 @default.
• W1993875100 hasConcept C46141821 @default.
• W1993875100 hasConcept C4839761 @default.
• W1993875100 hasConcept C55493867 @default.
• W1993875100 hasConcept C66974803 @default.
• W1993875100 hasConcept C67787023 @default.
• W1993875100 hasConcept C71240020 @default.
• W1993875100 hasConcept C84935128 @default.
• W1993875100 hasConceptScore W1993875100C121332964 @default.
• W1993875100 hasConceptScore W1993875100C1276947 @default.
• W1993875100 hasConceptScore W1993875100C185592680 @default.
• W1993875100 hasConceptScore W1993875100C2777477808 @default.
• W1993875100 hasConceptScore W1993875100C2779896295 @default.
• W1993875100 hasConceptScore W1993875100C2781123555 @default.
• W1993875100 hasConceptScore W1993875100C46141821 @default.
• W1993875100 hasConceptScore W1993875100C4839761 @default.
• W1993875100 hasConceptScore W1993875100C55493867 @default.
• W1993875100 hasConceptScore W1993875100C66974803 @default.

• next