FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993876144> ?p ?o ?g. }

• W1993876144 endingPage "569" @default.
• W1993876144 startingPage "562" @default.
• W1993876144 abstract "Directed screening of compounds selected from the Glaxo registry file for contractile activity on the isolated guinea pig gallbladder (GPGB) identified a series of 1,5-benzodiazepines with peripheral cholecystokinin (CCK) receptor agonist activity. Agonist efficacy within this series was modulated by variation of substituents on the N1-anilinoacetamide moiety. Remarkably, a single methyl group confers agonist activity, with an N-isopropyl substituent providing optimal efficacy. Hydrophilic substituents on the anilino nitrogen abolish agonist activity or produce antagonists of CCK. In contrast, hydrophilic electron-donating groups at the para-position of the anilino ring enhance or maintain in vitro and in vivo agonist activity. Despite decreased affinity for the human CCK-A receptor, relative to CCK-8, some of these compounds are equipotent to CCK as anorectic agents in rats following intraperitoneal administration." @default.
• W1993876144 created "2016-06-24" @default.
• W1993876144 creator A5007891580 @default.
• W1993876144 creator A5017853209 @default.
• W1993876144 creator A5032564403 @default.
• W1993876144 creator A5043774821 @default.
• W1993876144 creator A5044963635 @default.
• W1993876144 creator A5045145310 @default.
• W1993876144 creator A5049684435 @default.
• W1993876144 creator A5051640717 @default.
• W1993876144 creator A5054875393 @default.
• W1993876144 creator A5059727608 @default.
• W1993876144 creator A5060697254 @default.
• W1993876144 creator A5063055937 @default.
• W1993876144 creator A5064952409 @default.
• W1993876144 creator A5067153498 @default.
• W1993876144 creator A5074499951 @default.
• W1993876144 creator A5077934044 @default.
• W1993876144 creator A5087242967 @default.
• W1993876144 creator A5087290885 @default.
• W1993876144 creator A5090078656 @default.
• W1993876144 date "1996-01-01" @default.
• W1993876144 modified "2023-09-26" @default.
• W1993876144 title "Discovery of 1,5-Benzodiazepines with Peripheral Cholecystokinin (CCK-A) Receptor Agonist Activity. 1. Optimization of the Agonist “Trigger”" @default.
• W1993876144 cites W1935853419 @default.
• W1993876144 cites W1981493631 @default.
• W1993876144 cites W1990109135 @default.
• W1993876144 cites W2027513761 @default.
• W1993876144 cites W2035807640 @default.
• W1993876144 cites W2038552915 @default.
• W1993876144 cites W2069828003 @default.
• W1993876144 cites W2071695026 @default.
• W1993876144 cites W2085447050 @default.
• W1993876144 cites W2093053031 @default.
• W1993876144 cites W2096048736 @default.
• W1993876144 cites W2126681559 @default.
• W1993876144 cites W2163865126 @default.
• W1993876144 cites W2273336745 @default.
• W1993876144 doi "https://doi.org/10.1021/jm950626d" @default.
• W1993876144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8558528" @default.
• W1993876144 hasPublicationYear "1996" @default.
• W1993876144 type Work @default.
• W1993876144 sameAs 1993876144 @default.
• W1993876144 citedByCount "97" @default.
• W1993876144 countsByYear W19938761442012 @default.
• W1993876144 countsByYear W19938761442013 @default.
• W1993876144 countsByYear W19938761442014 @default.
• W1993876144 countsByYear W19938761442015 @default.
• W1993876144 countsByYear W19938761442016 @default.
• W1993876144 countsByYear W19938761442018 @default.
• W1993876144 countsByYear W19938761442020 @default.
• W1993876144 countsByYear W19938761442021 @default.
• W1993876144 countsByYear W19938761442022 @default.
• W1993876144 crossrefType "journal-article" @default.
• W1993876144 hasAuthorship W1993876144A5007891580 @default.
• W1993876144 hasAuthorship W1993876144A5017853209 @default.
• W1993876144 hasAuthorship W1993876144A5032564403 @default.
• W1993876144 hasAuthorship W1993876144A5043774821 @default.
• W1993876144 hasAuthorship W1993876144A5044963635 @default.
• W1993876144 hasAuthorship W1993876144A5045145310 @default.
• W1993876144 hasAuthorship W1993876144A5049684435 @default.
• W1993876144 hasAuthorship W1993876144A5051640717 @default.
• W1993876144 hasAuthorship W1993876144A5054875393 @default.
• W1993876144 hasAuthorship W1993876144A5059727608 @default.
• W1993876144 hasAuthorship W1993876144A5060697254 @default.
• W1993876144 hasAuthorship W1993876144A5063055937 @default.
• W1993876144 hasAuthorship W1993876144A5064952409 @default.
• W1993876144 hasAuthorship W1993876144A5067153498 @default.
• W1993876144 hasAuthorship W1993876144A5074499951 @default.
• W1993876144 hasAuthorship W1993876144A5077934044 @default.
• W1993876144 hasAuthorship W1993876144A5087242967 @default.
• W1993876144 hasAuthorship W1993876144A5087290885 @default.
• W1993876144 hasAuthorship W1993876144A5090078656 @default.
• W1993876144 hasConcept C126322002 @default.
• W1993876144 hasConcept C150903083 @default.
• W1993876144 hasConcept C170493617 @default.
• W1993876144 hasConcept C185592680 @default.
• W1993876144 hasConcept C207001950 @default.
• W1993876144 hasConcept C2777593968 @default.
• W1993876144 hasConcept C2778938600 @default.
• W1993876144 hasConcept C32110497 @default.
• W1993876144 hasConcept C38533456 @default.
• W1993876144 hasConcept C55493867 @default.
• W1993876144 hasConcept C58732023 @default.
• W1993876144 hasConcept C71240020 @default.
• W1993876144 hasConcept C71924100 @default.
• W1993876144 hasConcept C86803240 @default.
• W1993876144 hasConcept C98274493 @default.
• W1993876144 hasConceptScore W1993876144C126322002 @default.
• W1993876144 hasConceptScore W1993876144C150903083 @default.
• W1993876144 hasConceptScore W1993876144C170493617 @default.
• W1993876144 hasConceptScore W1993876144C185592680 @default.
• W1993876144 hasConceptScore W1993876144C207001950 @default.
• W1993876144 hasConceptScore W1993876144C2777593968 @default.
• W1993876144 hasConceptScore W1993876144C2778938600 @default.
• W1993876144 hasConceptScore W1993876144C32110497 @default.
• W1993876144 hasConceptScore W1993876144C38533456 @default.
• W1993876144 hasConceptScore W1993876144C55493867 @default.

• next