Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993876295> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W1993876295 abstract "Telomeric single-stranded G-overhangs are required for protecting chromosome ends and for telomerase elongation of telomeres. However, the molecular mechanism for G-overhang generation at human telomeres is unclear. We report here that G-overhangs undergo cell cycle-regulated dynamic changes independent of telomerase activity. G-overhangs are lengthened during S phase due to extensive C-strand resection, and shortened at G2 phase as a result of C-strand fill-in. This delayed C-strand fill-in is mediated by lagging-strand polymerases and regulated by cyclin-dependent kinase 1. Inhibiting C-strand fill-in induces telomere DNA damage response and a G2 arrest, suggesting a critical role of proper G-overhang generation in maintaining genome stability. In addition, the last nucleotide at C-strand remains precisely defined throughout the cell cycle. Our results indicate that both C-strand resection and fill-in are strictly regulated during the cell cycle to ensure proper G-overhang generation, and unveil an essential role of C-stand fill-in in maintaining functional telomeres.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3214." @default.
- W1993876295 created "2016-06-24" @default.
- W1993876295 creator A5045949951 @default.
- W1993876295 creator A5074181295 @default.
- W1993876295 date "2010-04-15" @default.
- W1993876295 modified "2023-10-16" @default.
- W1993876295 title "Abstract 3214: C-strand fill-in at human telomeres requires lagging strand synthesis machinery and is essential for maintaining functional telomeres" @default.
- W1993876295 doi "https://doi.org/10.1158/1538-7445.am10-3214" @default.
- W1993876295 hasPublicationYear "2010" @default.
- W1993876295 type Work @default.
- W1993876295 sameAs 1993876295 @default.
- W1993876295 citedByCount "0" @default.
- W1993876295 crossrefType "proceedings-article" @default.
- W1993876295 hasAuthorship W1993876295A5045949951 @default.
- W1993876295 hasAuthorship W1993876295A5074181295 @default.
- W1993876295 hasConcept C104317684 @default.
- W1993876295 hasConcept C153911025 @default.
- W1993876295 hasConcept C177336024 @default.
- W1993876295 hasConcept C185592680 @default.
- W1993876295 hasConcept C54355233 @default.
- W1993876295 hasConcept C552990157 @default.
- W1993876295 hasConcept C86803240 @default.
- W1993876295 hasConcept C94581717 @default.
- W1993876295 hasConcept C95444343 @default.
- W1993876295 hasConceptScore W1993876295C104317684 @default.
- W1993876295 hasConceptScore W1993876295C153911025 @default.
- W1993876295 hasConceptScore W1993876295C177336024 @default.
- W1993876295 hasConceptScore W1993876295C185592680 @default.
- W1993876295 hasConceptScore W1993876295C54355233 @default.
- W1993876295 hasConceptScore W1993876295C552990157 @default.
- W1993876295 hasConceptScore W1993876295C86803240 @default.
- W1993876295 hasConceptScore W1993876295C94581717 @default.
- W1993876295 hasConceptScore W1993876295C95444343 @default.
- W1993876295 hasLocation W19938762951 @default.
- W1993876295 hasOpenAccess W1993876295 @default.
- W1993876295 hasPrimaryLocation W19938762951 @default.
- W1993876295 hasRelatedWork W1972192032 @default.
- W1993876295 hasRelatedWork W2024737242 @default.
- W1993876295 hasRelatedWork W2049896711 @default.
- W1993876295 hasRelatedWork W2058439491 @default.
- W1993876295 hasRelatedWork W2071021106 @default.
- W1993876295 hasRelatedWork W2079015948 @default.
- W1993876295 hasRelatedWork W2080058515 @default.
- W1993876295 hasRelatedWork W2084492257 @default.
- W1993876295 hasRelatedWork W2089418437 @default.
- W1993876295 hasRelatedWork W2090517238 @default.
- W1993876295 hasRelatedWork W2135321245 @default.
- W1993876295 hasRelatedWork W2145631429 @default.
- W1993876295 hasRelatedWork W221818222 @default.
- W1993876295 hasRelatedWork W2740847816 @default.
- W1993876295 hasRelatedWork W2966511202 @default.
- W1993876295 hasRelatedWork W3019893461 @default.
- W1993876295 hasRelatedWork W3105065512 @default.
- W1993876295 hasRelatedWork W3145520013 @default.
- W1993876295 hasRelatedWork W428694034 @default.
- W1993876295 hasRelatedWork W2590980543 @default.
- W1993876295 isParatext "false" @default.
- W1993876295 isRetracted "false" @default.
- W1993876295 magId "1993876295" @default.
- W1993876295 workType "article" @default.