FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1993876306> ?p ?o ?g. }

• W1993876306 endingPage "288" @default.
• W1993876306 startingPage "283" @default.
• W1993876306 abstract "S-nitrosothiol compounds are important mediators of NO signalling and can give rise to various redox derivatives of NO: nitrosonium cation (NO+), nitroxyl anion (NO−) and NO• radical. Several enzymes and transporters have been implicated in the intracellular delivery of NO from S-nitrosothiols. In the present study we have investigated the role of GPx (glutathione peroxidase), the L-AT (L-amino acid transporter) system and PDI (protein disulfide-isomerase) in the delivery of NO redox derivatives into human platelets. Washed human platelets were treated with inhibitors of GPx, L-AT and PDI prior to exposure to donors of NO redox derivatives (S-nitrosoglutathione, Angeli's salt and diethylamine NONOate). Rapid delivery of NO-related signalling into platelets was monitored by cGMP accumulation and DAF-FM (4-amino-5-methylamino-2′7′-difluorofluorescein) fluorescence. All NO redox donors produced both a cGMP response and DAF-FM fluorescence in target platelets. NO delivery was blocked by inhibition of PDI in a dose-dependent manner. In contrast, inhibition of GPx and L-AT had only a minimal effect on NO-related signalling. PDI activity is therefore required for the rapid delivery into platelets of NO-related signals from donors of all NO redox derivatives. GPx and the L-AT system appeared to be unimportant in rapid NO signalling by the compounds used in the present study. This does not, however, exclude a possible role during exposure of cells to other S-nitrosothiol compounds, such as S-nitrosocysteine. These results further highlight the importance of PDI in mediating the action of a wide range of NO-related signals." @default.
• W1993876306 created "2016-06-24" @default.
• W1993876306 creator A5001828801 @default.
• W1993876306 creator A5055823786 @default.
• W1993876306 creator A5067755961 @default.
• W1993876306 date "2007-03-26" @default.
• W1993876306 modified "2023-10-02" @default.
• W1993876306 title "Protein disulfide-isomerase mediates delivery of nitric oxide redox derivatives into platelets" @default.
• W1993876306 cites W1483748949 @default.
• W1993876306 cites W1488493608 @default.
• W1993876306 cites W1857559494 @default.
• W1993876306 cites W1872105221 @default.
• W1993876306 cites W1964996063 @default.
• W1993876306 cites W1966551859 @default.
• W1993876306 cites W1993305373 @default.
• W1993876306 cites W2001840182 @default.
• W1993876306 cites W2004780745 @default.
• W1993876306 cites W2005515164 @default.
• W1993876306 cites W2014561544 @default.
• W1993876306 cites W2017104014 @default.
• W1993876306 cites W2019899535 @default.
• W1993876306 cites W2022466310 @default.
• W1993876306 cites W2030495727 @default.
• W1993876306 cites W2043475869 @default.
• W1993876306 cites W2047609920 @default.
• W1993876306 cites W2049505174 @default.
• W1993876306 cites W2062802606 @default.
• W1993876306 cites W2075359708 @default.
• W1993876306 cites W2075473361 @default.
• W1993876306 cites W2077828053 @default.
• W1993876306 cites W2078767770 @default.
• W1993876306 cites W2081376324 @default.
• W1993876306 cites W2085987303 @default.
• W1993876306 cites W2086605651 @default.
• W1993876306 cites W2088378615 @default.
• W1993876306 cites W2123550664 @default.
• W1993876306 cites W2129415401 @default.
• W1993876306 cites W2141522397 @default.
• W1993876306 cites W2146206984 @default.
• W1993876306 cites W2164116069 @default.
• W1993876306 cites W2169232518 @default.
• W1993876306 cites W2260433292 @default.
• W1993876306 cites W2467657054 @default.
• W1993876306 cites W4251880775 @default.
• W1993876306 doi "https://doi.org/10.1042/bj20061146" @default.
• W1993876306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1874238" @default.
• W1993876306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17176252" @default.
• W1993876306 hasPublicationYear "2007" @default.
• W1993876306 type Work @default.
• W1993876306 sameAs 1993876306 @default.
• W1993876306 citedByCount "39" @default.
• W1993876306 countsByYear W19938763062012 @default.
• W1993876306 countsByYear W19938763062013 @default.
• W1993876306 countsByYear W19938763062014 @default.
• W1993876306 countsByYear W19938763062015 @default.
• W1993876306 countsByYear W19938763062016 @default.
• W1993876306 countsByYear W19938763062018 @default.
• W1993876306 countsByYear W19938763062019 @default.
• W1993876306 countsByYear W19938763062021 @default.
• W1993876306 countsByYear W19938763062022 @default.
• W1993876306 crossrefType "journal-article" @default.
• W1993876306 hasAuthorship W1993876306A5001828801 @default.
• W1993876306 hasAuthorship W1993876306A5055823786 @default.
• W1993876306 hasAuthorship W1993876306A5067755961 @default.
• W1993876306 hasBestOaLocation W19938763062 @default.
• W1993876306 hasConcept C178790620 @default.
• W1993876306 hasConcept C181199279 @default.
• W1993876306 hasConcept C185592680 @default.
• W1993876306 hasConcept C203014093 @default.
• W1993876306 hasConcept C2776015013 @default.
• W1993876306 hasConcept C2776142628 @default.
• W1993876306 hasConcept C5098756 @default.
• W1993876306 hasConcept C519581460 @default.
• W1993876306 hasConcept C538909803 @default.
• W1993876306 hasConcept C55493867 @default.
• W1993876306 hasConcept C55904794 @default.
• W1993876306 hasConcept C79879829 @default.
• W1993876306 hasConcept C86803240 @default.
• W1993876306 hasConcept C89560881 @default.
• W1993876306 hasConceptScore W1993876306C178790620 @default.
• W1993876306 hasConceptScore W1993876306C181199279 @default.
• W1993876306 hasConceptScore W1993876306C185592680 @default.
• W1993876306 hasConceptScore W1993876306C203014093 @default.
• W1993876306 hasConceptScore W1993876306C2776015013 @default.
• W1993876306 hasConceptScore W1993876306C2776142628 @default.
• W1993876306 hasConceptScore W1993876306C5098756 @default.
• W1993876306 hasConceptScore W1993876306C519581460 @default.
• W1993876306 hasConceptScore W1993876306C538909803 @default.
• W1993876306 hasConceptScore W1993876306C55493867 @default.
• W1993876306 hasConceptScore W1993876306C55904794 @default.
• W1993876306 hasConceptScore W1993876306C79879829 @default.
• W1993876306 hasConceptScore W1993876306C86803240 @default.
• W1993876306 hasConceptScore W1993876306C89560881 @default.
• W1993876306 hasIssue "2" @default.
• W1993876306 hasLocation W19938763061 @default.
• W1993876306 hasLocation W19938763062 @default.
• W1993876306 hasLocation W19938763063 @default.
• W1993876306 hasLocation W19938763064 @default.

• next